PT  - JOURNAL ARTICLE
AU  - Christian Eick
AU  - Patrick Groga-Bada
AU  - Kathrin Reinhardt
AU  - Martin Duckheim
AU  - Lars Mizera
AU  - Katharina Böhm
AU  - Nina Götz
AU  - Meinrad Gawaz
AU  - Christine Zürn
TI  - Nocturnal respiratory rate as a predictor of mortality in patients with acute coronary syndrome
AID  - 10.1136/openhrt-2018-000887
DP  - 2018 Nov 01
TA  - Open Heart
PG  - e000887
VI  - 5
IP  - 2
4099  - http://openheart.bmj.com/content/5/2/e000887.short
4100  - http://openheart.bmj.com/content/5/2/e000887.full
SO  - Open Heart2018 Nov 01; 5
AB  - Background Patients with acute coronary syndrome (ACS) are at risk especially in the period shortly after the event. Alterations in respiratory control have been associated with adverse prognosis. The aim of our study was to assess if the nocturnal respiratory rate (NRR) is a predictor of mortality in patients with ACS presenting in the emergency department.Methods Clinically stable consecutive patients with ACS aged ≥ 18 years were prospectively enrolled. The Global Registry of Acute Coronary Events (GRACE) score and left ventricular ejection fraction (LVEF) were assessed for all patients. The average NRR over a period of 6  hours was determined by the records of the surveillance monitors in the first night after admission. Primary and secondary endpoints were intrahospital and 2  years all-cause mortality, respectively.Results Of the 860 patients with ACS, 21 (2.4%) died within the intrahospital phase and 108 patients (12.6%) died within the subsequent 2 years. The NRR was a significant predictor of both endpoints and was independent from the GRACE score and LVEF. Implementing the NRR into the GRACE risk model leads to a significant increase of the C-statistics especially for prediction of intrahospital mortality.Conclusion The NRR is an independent predictor of mortality in patients with ACS.