RT Journal Article
SR Electronic
T1 Decrease in exhaled hydrogen as marker of congestive heart failure
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e000814
DO 10.1136/openhrt-2018-000814
VO 5
IS 2
A1 Atsushi Shibata
A1 Yasuo Sugano
A1 Akito Shimouchi
A1 Tetsuro Yokokawa
A1 Naoya Jinno
A1 Hideaki Kanzaki
A1 Keiko Ohta-Ogo
A1 Yoshihiko Ikeda
A1 Hideshi Okada
A1 Takeshi Aiba
A1 Kengo Kusano
A1 Mikiyasu Shirai
A1 Hatsue Ishibashi-Ueda
A1 Satoshi Yasuda
A1 Hisao Ogawa
A1 Toshihisa Anzai
YR 2018
UL http://openheart.bmj.com/content/5/2/e000814.abstract
AB Objective Hydrogen excretion is thought to be related to systemic antioxidation activity. H2 selectively reduces the hydroxyl radical of free hydrogen (·OH), a highly cytotoxic form of reactive oxygen species, in cultured cells.Methods We investigated whether exhaled H2 decreased during night sleep, reflected ·OH production and was associated with heart failure severity. We enrolled 108 patients with chronic heart failure (CHF) and 15 control participants without CHF. H2 concentration was measured by gas chromatography in exhaled breath collected before sleep and in the morning after overnight fasting. Overnight change in H2 concentration (ΔH2) was calculated. Mitochondrial morphology evaluated by transmission electron microscopy in endomyocardial biopsies collected from 18 patients with dilated cardiomyopathy.Results ΔH2 was significantly lower in patients with CHF compared with controls (−4.3±1.0 vs 2.0±2.1 ppm, p=0.030) and was positively correlated with cardiac index (CI; r = −0.285, p=0.003). Patients with a ΔH2<0 ppm had a significantly lower CI compared with those who had a ΔH2>0 ppm (2.85±0.61 vs 3.24±0.65 L/min/m2, p=0.005). ΔH2 was negatively correlated with both the percentage of vacuole-containing mitochondria and indices of cristae remodelling (r = −0.61, p=0.007).Conclusions Decrease in exhaled H2 during night sleep was associated with CHF severity. ΔH2 warrants investigation as marker of CHF severity.