@article {Vestberge000727, author = {Daniel Vestberg and Annika Rosengren and Katarina Eeg-Olofsson and Mervete Miftaraj and Stefan Franzen and Ann-Marie Svensson and Marcus Lind}, title = {Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes}, volume = {5}, number = {1}, elocation-id = {e000727}, year = {2018}, doi = {10.1136/openhrt-2017-000727}, publisher = {Archives of Disease in childhood}, abstract = {Objective To investigate the potential relationship between body mass index (BMI) and the risk for myocardial infarction and coronary death in patients with type 1 diabetes.Methods We studied patients with type 1 diabetes included in the Swedish National Diabetes Registry during 2002{\textendash}2004 and followed them until a discharge diagnosis for myocardial infarction, acute coronary event, death or until 31 December 2011. Cox regression was used to estimate relative risks.Results In 17 499 patients with type 1 diabetes (mean age 39.4 years; mean BMI 25.2 kg/m2), 819 were diagnosed with myocardial infarction as a primary or secondary diagnosis during a mean follow-up of 8.5 years (maximum 9.9 years). Estimated with Cox regression, there was no significant effect of increased BMI on the risk of myocardial infarction (HR 1.4 (95\% CI 0.7 to 2.5) in the group with BMI \>35 kg/m2 compared with BMI 18.5{\textendash}25 kg/m2. There was no association between BMI and coronary mortality, acute coronary events or all-cause mortality after adjusting for other known risk factors. Underweight patients (BMI \<18.5 kg/m2) had increased hazard for coronary (HR 5.0 (95\% CI 1.5 to 16.9)) and all-cause mortality (HR 5.4 (95\% CI 3.1 to 9.6)) compared with BMI 18.5{\textendash}25 kg/m2.Conclusions Among patients with type 1 diabetes, increased BMI is not a significant independent risk factor for myocardial infarction or coronary death after adjustment for other risk factors. Low BMI (less than 18.5 kg/m2) is associated with mortality from coronary or any cause.}, URL = {https://openheart.bmj.com/content/5/1/e000727}, eprint = {https://openheart.bmj.com/content/5/1/e000727.full.pdf}, journal = {Open Heart} }