RT Journal Article SR Electronic T1 Impact of nutritional indices on mortality in patients with heart failure JF Open Heart JO Open Heart FD British Cardiovascular Society SP e000730 DO 10.1136/openhrt-2017-000730 VO 5 IS 1 A1 Akiomi Yoshihisa A1 Yuki Kanno A1 Shunsuke Watanabe A1 Tetsuro Yokokawa A1 Satoshi Abe A1 Makiko Miyata A1 Takamasa Sato A1 Satoshi Suzuki A1 Masayoshi Oikawa A1 Atsushi Kobayashi A1 Takayoshi Yamaki A1 Hiroyuki Kunii A1 Kazuhiko Nakazato A1 Hitoshi Suzuki A1 Takafumi Ishida A1 Yasuchika Takeishi YR 2018 UL http://openheart.bmj.com/content/5/1/e000730.abstract AB Background Malnutrition is a common condition that is associated with adverse prognosis in patients with heart failure (HF). The Prognostic Nutritional Index (PNI), Geriatric Nutritional Risk Index (GNRI) and controlling nutritional status (CONUT) have all been used as objective indices for evaluating nutritional status. We aimed to clarify the relationship between these nutritional indices and the parameters of inflammatory markers, cardiac function and exercise capacity, as well as to compare the ability of these indexes for predicting mortality.Methods We evaluated PNI, GNRI and CONUT in consecutive 1307 patients with HF.Results First, there were significant correlations between nutritional indices and the following: C reactive protein; tumour necrosis factor-α; adiponectin; B-type natriuretic peptide; troponin I; inferior vena cava diameter and peak VO2 (P<0.05, respectively). Second, in the Kaplan-Meier analysis (follow-up 1146 days), all-cause mortality progressively increased from normal to mild, moderate and severe disturbance groups in the indices (log-rank, P<0.01, respectively). In the Cox proportional hazard analysis, each index was an independent predictor of all-cause mortality in patients with HF (P<0.001, respectively). Third, receiver operating curve demonstrated that the areas under the curve of PNI and GNRI were larger than that of CONUT score (P<0.05, respectively).Conclusion Patients with HF being malnourished had higher mortality accompanied by higher levels of C reactive protein, tumour necrosis factor-α, adiponectin, B-type natriuretic peptide, troponin I, right-sided volume overload and impaired exercise capacity, rather than left ventricular systolic function. Additionally, PNI and GNRI were superior to CONUT score in predicting mortality in patients with HF.