TY - JOUR T1 - Morbidity outcomes after surgical aortic valve replacement JF - Open Heart JO - Open Heart DO - 10.1136/openhrt-2017-000588 VL - 4 IS - 1 SP - e000588 AU - Andreas Auensen AU - Amjad Iqbal Hussain AU - Bjørn Bendz AU - Lars Aaberge AU - Ragnhild Sørum Falk AU - Marte Meyer Walle-Hansen AU - Jorun Bye AU - Johanna Andreassen AU - Jan Otto Beitnes AU - Kjell Arne Rein AU - Kjell Ingar Pettersen AU - Lars Gullestad Y1 - 2017/04/01 UR - http://openheart.bmj.com/content/4/1/e000588.abstract N2 - Objective In patients with mild to moderate operative risk, surgical aortic valve replacement (SAVR) is still the preferred treatment for patients with severe symptomatic aortic stenosis (AS). Aiming to broaden the knowledge of postsurgical outcomes, this study reports a broad set of morbidity outcomes following surgical intervention.Methods Our cohort comprised 442 patients referred for severe AS; 351 had undergone SAVR, with the remainder (91) not operated on. All patients were evaluated using the 6-minute walk test (6MWT), were assigned a New York Heart Association class (NYHA) and Canadian Cardiovascular Society class (CCS), with additional scores for health-related quality of life (HRQoL), cognitive function (Mini-Mental State Examination (MMSE)) and myocardial remodelling (at inclusion and at 1-year follow-up). Adverse events and mortality were recorded.Results Three-year survival after SAVR was 90.0%. SAVR was associated with an improved NYHA class, CCS score and HRQoL, and provoked reverse ventricular remodelling. The 6MWT decreased, while the risks of major adverse cardiovascular events (death, non-fatal stroke/transient ischaemic attack or myocardial infarction) and all-cause hospitalisation (incidence rate per 100 patient-years) were 13.5 and 62.4, respectively. The proportion of cognitive disability measured by MMSE increased after SAVR from 3.2% to 8.8% (p=0.005). Proportion of patients living independently at home, having attained NYHA class I, was met by 49.1% at 1 year. Unoperated individuals had a poor prognosis in terms of any outcome.Conclusion This study provides knowledge of outcomes beyond what is known about the mortality benefit after SAVR to provide insight into the morbidity burden of modern-day SAVR. ER -