RT Journal Article
SR Electronic
T1 The 7-year teesside experience of primary prevention ICD indications following primary PCI (PPCI) and the potential impact of a change in NICE guidance
JF Open Heart
JO Open Heart
FD British Cardiovascular Society
SP e000153
DO 10.1136/openhrt-2014-000153
VO 2
IS 1
A1 Thanh Trung Phan
A1 Saima Khan
A1 Muhammad Muzaffar Mahmood
A1 Sudha Mani
A1 Vineet Wadehra
A1 Mark de Belder
A1 Andrew Thornley
A1 Simon James
A1 Nicholas J Linker
A1 Andrew J Turley
YR 2015
UL http://openheart.bmj.com/content/2/1/e000153.abstract
AB Introduction The recovery of LV function in patients with severe LV impairment in the acute phase following primary percutaneous coronary intervention (PPCI) is not well established. The indication for a primary prevention ICD post-STEMI is dependent on which screening guidance, NICE or ESC, is followed. The potential impact of the new NICE guidance is estimated.Methods We performed a retrospective analysis of all patients presenting with a STEMI over a 7-year period (2005–2012) treated with PPCI to determine in-hospital mortality, LV function at index presentation, at 3 months and the predicted primary prevention ICD implantation rate using NICE (TA095) and ESC 2006 guidelines. Predicted implant rates using the new NICE guidance (TA314) and actual implantation rates were also assessed.Results 3902 patients with a mean age of 65±13 years underwent PPCI. Of those patients surviving until discharge, 332 (10%) had LVEF ≤35%. 254 of 332 patients (76%) with a severely impaired ventricle were followed up at participating centres. 210 of 254 (83%) patients had a repeat echocardiogram within 3 months post-MI; among these patients, 89 (42%) remained to have LVEF ≤35%. The number of patients fulfilling NICE and ESC criteria for primary prevention ICD implantation was 14 (16%) and 84 (94%), respectively. The actual number of patients receiving an ICD was 17 (19%). The number of patients fulfilling the new NICE (TA314) guidance was 84 (94%).Conclusions A small proportion of patients with STEMIs undergoing PPCI have a severely impaired LV systolic function. A large proportion of these patients will have improved LV systolic function at 3 months. There is a five-fold difference in the predicted ICD implantation rates depending on which guidance is followed—NICE versus ESC. The potential impact of the new NICE (TA314) guidance on ICD implantation will be a significant increase in ICD implantation rates.