Article Text

Download PDFPDF

Review
Manipulation of ACE2 expression in COVID-19
  1. Farhan Chaudhry1,
  2. Sergio Lavandero2,3,
  3. Xiang Xie4,
  4. Basera Sabharwal5,
  5. Ying-Ying Zheng4,
  6. Ashish Correa5,
  7. Jagat Narula5 and
  8. Phillip Levy1
  1. 1Department of Emergency Medicine and Integrative Biosciences Center, Wayne State University School of Medicine, Detroit, Michigan, USA
  2. 2Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Quimicas y Farmaceuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile
  3. 3Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
  4. 4Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China
  5. 5Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  1. Correspondence to Dr Farhan Chaudhry; gf9603{at}wayne.edu

Abstract

SARS-CoV-2 is the virus responsible for the ongoing COVID-19 outbreak. The virus uses ACE2 receptor for viral entry. ACE2 is part of the counter-regulatory renin-angiotensin-aldosterone system and is also expressed in the lower respiratory tract along the alveolar epithelium. There is, however, significant controversy regarding the role of ACE2 expression in COVID-19 pathogenesis. Some have argued that decreasing ACE2 expression would result in decreased susceptibility to the virus by decreasing available binding sites for SARS-CoV-2 and restricting viral entry into the cells. Others have argued that, like the pathogenesis of other viral pneumonias, including those stemming from previous severe acute respiratory syndrome (SARS) viruses, once SARS-CoV-2 binds to ACE2, it downregulates ACE2 expression. Lack of the favourable effects of ACE2 might exaggerate lung injury by a variety of mechanisms. In order to help address this controversy, we conducted a literature search and review of relevant preclinical and clinical publications pertaining to SARS-CoV-2, COVID-19, ACE2, viral pneumonia, SARS, acute respiratory distress syndrome and lung injury. Our review suggests, although controversial, that patients at increased susceptibility to COVID-19 complications may have reduced baseline ACE2, and by modulating ACE2 expression one can possibly improve COVID-19 outcomes. Herein, we elucidate why and how this potential mechanism might work.

  • hypertension
  • intensive care
  • lung injury
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors FC is the first author and compiled this review. SL, XX, BS, Y-YZ, AC, JN and PL provided equal contributions to different aspects of the review.

  • Funding This work was supported by grants from the Agencia Nacional de Investigacion y Desarrollo (ANID), Chile: FONDAP 15130011 and FONDECYT 1200490 (to SL).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The paper is a review and did not require ethical approval from any institution.

  • Data availability statement Data sharing not applicable as no datasets generated and/or analysed for this study.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.