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  • Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

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Heart failure and cardiomyopathies
Review
Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Authors

  • Emil Eik Nielsen Department of Internal Medicine – Cardiology Section, Holbaek Hospital, Holbaek, DenmarkInstitute of Regional Health Research, University of Southern Denmark, Odense, Denmark PubMed articlesGoogle scholar articles
  • Joshua Buron Feinberg Department of Internal Medicine – Cardiology Section, Holbaek Hospital, Holbaek, DenmarkInstitute of Regional Health Research, University of Southern Denmark, Odense, Denmark PubMed articlesGoogle scholar articles
  • Fan-Long Bu Beijing Children's Hospital, Capital Medical University, Beijing, China PubMed articlesGoogle scholar articles
  • Michael Hecht Olsen Department of Internal Medicine – Cardiology Section, Holbaek Hospital, Holbaek, DenmarkInstitute of Regional Health Research, University of Southern Denmark, Odense, DenmarkCentre for Individualized Medicine in Arterial Diseases (CIMA), Odense University Hospital, University of Southern Denmark, Odense, Denmark PubMed articlesGoogle scholar articles
  • Ilan Raymond Department of Internal Medicine – Cardiology Section, Holbaek Hospital, Holbaek, Denmark PubMed articlesGoogle scholar articles
  • Frank Steensgaard-Hansen Department of Internal Medicine – Cardiology Section, Holbaek Hospital, Holbaek, Denmark PubMed articlesGoogle scholar articles
  • Janus Christian Jakobsen Institute of Regional Health Research, University of Southern Denmark, Odense, DenmarkCopenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Emil Eik Nielsen; Emil.eik.nielsen{at}gmail.com
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Citation

Nielsen EE, Feinberg JB, Bu F, et al
Beneficial and harmful effects of sacubitril/valsartan in patients with heart failure: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
Open Heart 2020;7:e001294. doi: 10.1136/openhrt-2020-001294

Publication history

  • Received March 30, 2020
  • Revision received September 10, 2020
  • Accepted October 26, 2020
  • First published November 30, 2020.
Online issue publication 
January 09, 2022

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.