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Original research
Hospital meal intake in acute heart failure patients and its association with long-term outcomes
  1. Taizo Yoshida1,
  2. Satoshi Shoji1,
  3. Yasuyuki Shiraishi1,
  4. Masataka Kawana2,
  5. Takashi Kohno3,
  6. Kenji Inoue4,
  7. Keiichi Fukuda1,
  8. Paul A Heidenreich2 and
  9. Shun Kohsaka1
  1. 1Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
  2. 2Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA
  3. 3Department of Cardiovascular Medicine, Kyorin University School of Medicine, Tokyo, Japan
  4. 4Department of Cardiology, Juntendo University Nerima Hospital, Tokyo, Japan
  1. Correspondence to Dr Shun Kohsaka; sk{at}keio.jp

Abstract

Background Risk prediction for hospitalised heart failure (HF, HHF) patients remains suboptimal. We aimed to determine the prognostic value of hospital food intake (FI) immediately before discharge among HHF patients.

Method We analysed the data of 255 HHF patients extracted from the records of a single university hospital. The FI percentage of the three meals the day before hospital discharge was averaged. Patients were stratified into adequate FI (100% consumption) and inadequate FI (less than 100% consumption) groups. The primary outcome was the composite of all-cause mortality and/or HF readmission within 1 year.

Results Only 49.3% of HHF patients consumed 100% of their meals. Patients with inadequate FI were older; predominantly women; and had a lower body mass index, higher brain natriuretic peptide levels and Clinical Frailty Scale scores at discharge than those with adequate FI. Inadequate FI was significantly associated with adverse outcomes after adjustments (HR 2.00; 95% CI 1.09 to 3.67; p=0.026). The effect of interaction by ejection fraction (EF) was highly significant: HF with preserved EF (≥40%) was significantly associated with inadequate FI with adverse outcomes (HR 4.95; 95% CI 1.71 to 14.36; p=0.003) but HF with reduced EF (<40%) was not (HR 0.77; 95% CI 0.31 to 1.95; p=0.590).

Conclusions The hospital FI assessment might be a simple, useful tool for predicting and stratifying risk for HHF patients.

  • heart failure
  • heart failure with normal ejection fraction
  • systolic heart failure
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Key questions

What is already known about this subject?

  • Food intake reflects the general condition of hospitalised patients, and decreased food intake is known to be associated with long-term prognosis among hospitalised patients.

What does this study add?

  • This is the first study to demonstrate the association between food intake and the long-term prognosis among hospitalised heart failure patients.

How might this impact on clinical practice?

  • The hospital food intake assessment might be a simple, useful tool for predicting and stratifying risk for hospitalised heart failure patients.

Introduction

Heart failure (HF) is the leading cause of hospitalisation and is associated with poor prognosis and high medical costs.1–3 Risk prediction is of paramount importance to tailor the management of patients with HF. Although numerous conventional risk predictors of HF have been established, such as brain natriuretic peptide (BNP), creatinine and troponin, these parameters require blood sampling and reflect isolated organ dysfunction rather than the general condition of the patient.4–8

Among various nontraditional clinical risk predictors, food intake (FI) is a simple, user-friendly assessment parameter that can be determined at the bedside and is considered to reflect the general condition of hospitalised patients. Several epidemiological studies of hospitalised patients demonstrated that decreased FI represents an independent risk factor for hospital mortality.9 Recently, Calleja Fernández et al showed a positive correlation between decreased FI and higher 30-day mortality among haematology-oncology patients.10 However, to the best of our knowledge, no studies have reported the association between FI and the mid-term prognosis of hospitalised HF (HHF) patients. Therefore, in this study, we aimed to investigate the prognostic association with hospital FI for HHF patients immediately before their discharge.

Methods

This study was conducted as a part of the West Tokyo Heart Failure Registry,11 a large, prospective, multicentre cohort registry designed to collect data regarding the clinical backgrounds and outcomes of patients hospitalised for HF. To assess the care and patient outcomes, baseline data and outcomes were collected from individual medical charts by trained clinical research coordinators. Data were entered into an electronic data-capturing system using a robust data query engine and system validations for data quality. Exclusive on-site auditing by the investigators (YS and SK) ensured proper registration by each patient. The objectives and detailed design data are stored on the University Hospital Medical Information Network (UMIN000001171).

Subjects

The data of 255 consecutive patients who were hospitalised for HF at Keio University Hospital between January 2012 and November 2016 were extracted (figure 1). HHF was defined as rapid-onset HF or a change in HF symptoms requiring urgent therapy and hospitalisation based on the Framingham criteria.1 Patients presenting with acute coronary syndrome were not included in this registry. Of the 255 patients, we excluded 13 (5.1%) who died during hospitalisation and, thus, whose mid-term prognosis could not be evaluated; 19 (7.5%) who were transferred to other hospitals for further care and rehabilitation and whose evaluated FI status did not coincide with complete recovery; 6 (2.4%) with dysphagia whose FI was restricted owing to reasons unrelated to their general status; and 10 (3.9%) who were lost to follow-up. We analysed the remaining 207 patients.

Figure 1

Flow chart of the study design. Adequate food intake (FI) is 100% consumption of food; inadequate FI is less than 100% consumption of food.

Hospital meal

Typical hospital meals in Japan consist of a main dish of meat or fish, vegetables and other such food items (figure 2A) and a side dish (bowl of rice). Main meals were plated cold or heated or kept cool in temperature-controlled delivery trolleys at the ward level. Salt intake was limited to 6 g/day for HHF patients, and protein intake restriction was recommended based on baseline kidney function. Patients were prescribed one of the following therapeutic diets ≥24 hours before the commencement of data collection, thereby allowing sufficient time for the staff to enter the diet prescription: soft, minced and moist, smooth pureed, mildly thick, moderately thick or extremely thick. During the hospitalisation, patients were provided breakfast, lunch and dinner; they were not allowed to bring any food from their home or visit the hospital cafeteria for nutrition education.

Figure 2

(A) A typical hospital meal in Japan: main dish (fish, vegetables and other food items such as salad and fruit) and side dish (rice bowl). (B) Distribution of food intake percentages (n=207). Adequate FI is 100% consumption of food; inadequate FI is less than 100% consumption of food.

Dietary assessment

Complete dietary provisions and intakes were directly observed, and nurses visually estimated FI percentages (FIP) after each hospital meal (the main dish and rice were estimated separately). This is the standard method in most hospitals in Japan; nurses take the training of standardised visual assessment of FI based on a hospital-wide implemented protocol.12 13 This dietary assessment is different from the nutritional assessment performed in the United States, in which a registered dietician routinely performs a ‘calorie count’ (counting how many calories the patients consumed).14 The consumption of each dietary item was recorded as a fraction of the whole portion on a 5-point scale with some flexibility, which has been shown to correlate closely with weighed dietary intake.15 One researcher (TY) independently collected all observational and chart audit data to eliminate inter-rater variability. The overall average percentage of the main dish and side dish intake were calculated for each meal, and FIP was calculated as the average percentage of the three meals (breakfast, lunch and dinner) during the day before hospital discharge. If data for the day before the hospital discharge were not available, then the last three FI data before discharge were used.

Primary outcomes

The primary outcome was defined as the composite outcome of all-cause death or readmission due to worsening HF within 1 year. Decisions regarding the need for readmission due to HF were made according to the directions of the treating physicians and according to standard practice. The exploratory secondary outcome comprised each separate outcome. Because of the exploratory nature of this study, the sample size was not predetermined.

Definition of other variables

The Clinical Frailty Scale (CFS) is a generally accepted semiquantitative measure of clinical frailty that can be easily measured by non-geriatricians.16 CFS scores were determined according to nurse records by a trained medical professional, according to the Canadian Study of Health and Aging grading criteria. CFS results were categorised into three groups as follows: non-frail (CFS score, 1–3), mildly frail (CFS score, 4–6) and severely frail (CFS score, 7–9).

The Seattle Heart Failure Model (SHFM) is a well-validated risk score for predicting the 1-year mortality of HF patients; it is calculated for each patient from 20 variables (age, sex, New York Heart Association functional classification, left ventricular ejection fraction (EF), ischaemic aetiology, systolic blood pressure, diuretic agent dose, angiotensin-converting enzyme inhibitor use, angiotensin receptor blocker use, beta-blocker use, antialdosterone antagonist use, allopurinol use, statin use, device therapy (intracardiac defibrillator (ICD) and cardiac resynchronisation therapy with or without ICD), lymphocyte percentage, serum sodium, total cholesterol, haemoglobin and uric acid).17 We previously validated the SHFM externally and internationally among Japanese patients with HF.18

Chronic kidney disease was defined as either kidney damage or a decreased estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2 for at least 3 months.19 Plasma BNP levels were measured on admission and at discharge.

Statistical analyses

Initially, the distribution of the FIP for the entire population was described (figure 2B). The association between FIP and CFS scores was assessed using Spearman’s correlation coefficient (online supplementary figure 1). Patients were categorised into two groups: inadequate FIP group (less than 100% consumed) and adequate FIP group (100% consumed) (table 1). Normality of continuous variables was tested using the Shapiro-Wilk test and/or Q-Q plot visual assessment. Continuous variables with normal distributions were expressed as mean±SD. Other variables were expressed as median (25th and 75th percentiles). Differences between groups were tested using Student’s t-tests or Mann-Whitney U tests for continuous variables and Pearson X2 tests for categorical variables. Patients with HF were also classified as those with HF with preserved EF (HFpEF, EF ≥40%) and HF with reduced EF (HFrEF, EF <40%). Moreover, baseline characteristics of the inadequate FIP group and the adequate FIP group were compared (online supplementary tables 1 and 2). In addition, the event-free rate of the primary outcome was estimated using the Kaplan-Meier method, and differences were assessed with the log-rank test (figure 3). To estimate the adjusted HRs of the association between FIP and the primary outcome, the Cox proportional hazards analysis was performed after adjusting for SHFM. In addition to the above, we conducted the subanalysis adjusting for SHFM and BNP levels at discharge.

Table 1

Baseline characteristics of the study population

Figure 3

(A) Kaplan-Meier survival curves for the primary outcome (all-cause death or heart failure readmission within 1 year). (B) Kaplan-Meier curves for the primary outcome according to the heart failure phenotypes: HFpEF (EF ≥40%) and heart failure with reduced EF (<40%). Adequate food intake (FI) is 100% consumption of food; inadequate FI is less than 100% consumption of food. EF, ejection fraction; HFpEF, heart failure with preserved EF; HFrEF, heart failure with reduced EF.

The association of the primary outcome with FI of the main dish and side dish was evaluated (online supplementary figure 2). Associations of FIP with individual components of the primary outcome (all-cause death and HF readmission) were also assessed (online supplementary figure 3A). To evaluate the robustness of our findings, a sensitivity analysis using different FIP cut-off values (90%) was performed (online supplementary figure 3B). Finally, an adjusted analysis of the subgroups relevant to HF prognosis was performed; the relevant variables were age (stratified by 75 years), sex, body mass index (BMI; stratified by 23 kg/m2), chronic kidney disease (stratified by 60% eGFR), EF (cut-off, 40%), BNP (stratified by the median) and albumin (stratified by the median) (online supplementary figure 4). All p values were two sided. Results were considered statistically significant at p<0.05. All statistical analyses were performed using SPSS V.24.0 (IBM).

Results

The mean age of the patients was 74 years, and 43% were women. Table 1 shows the baseline characteristics stratified by FIP. Compared with patients in the adequate FIP group, patients in the inadequate FIP group were older, predominantly female, had lower BMI, had lower haemoglobin levels, had lower eGFR and had higher CFS scores. Moreover, the inadequate FIP group had higher BNP levels at discharge (inadequate FIP: 306 (range, 191–612) pg/mL; adequate FIP: 185 (range, 81.6–353) pg/mL; p<0.001) and lower BNP change rates during hospitalisation (inadequate FIP: 49.3% (range, 29.2%–64.7%); adequate FIP: 68.1% (range, 43.3%–83.1%); p=0.001) (online supplementary figure 5). Baseline characteristics of HFpEF and HFrEF patients stratified by FIP are shown in online supplementary tables 1 and 2.

Median FIP was 98.3% (IQR, 81.7%–100%) (figure 2B), with 105 patients (50.7%) in the inadequate FIP group and 102 patients (49.3%) in the adequate FIP group. The association between FIP and CFS is shown in online supplementary figure 1. Spearman’s correlation coefficient revealed a significant negative correlation between FIP and CFS (r=−0.29; p<0.001).

A total of 59 patients (28.5%) attained the primary outcome: 40 were in the inadequate FIP group and 19 were in the adequate FIP group. The Kaplan-Meier curves showed that patients in the inadequate FIP group had a higher incidence of achieving the primary outcome (log-rank test; p=0.003) than those in the adequate FIP group (figure 3A). The association was preserved after the Cox regression analysis (HR 2.00; 95% CI 1.09 to 3.67; p=0.026). In the subanalysis adjusted for SHFM and BNP levels at discharge, the result was not statistically significant but directionally similar to our main finding (HR 1.69; 95% CI 0.82 to 3.45; p=0.153). HFpEF (EF ≥40%) was significantly associated with inadequate FI and the primary outcome (HR 4.95; 95% CI 1.71 to 14.36; p=0.003), whereas HFrEF (EF <40%) was not associated with FI (HR 0.77; 95% CI 0.31 to 1.95; p=0.590); the test for interaction with EF was highly significant (p=0.030) (figure 3B). A sensitivity analysis using a different EF cut-off value (50%) demonstrated the robustness of the result; HFpEF (EF ≥50%) was significantly associated with inadequate FI and the primary outcome (HR 5.58; 95% CI 1.64 to 19.04; p=0.006) but HFrEF (EF <50%) was not (HR 0.95; 95% CI 0.42 to 2.11; p=0.889).

When analysed individually, inadequate intake of the main dish was significantly associated with adverse outcomes (HR 2.36; 95% CI 1.31 to 4.25; p=0.004), whereas inadequate side dish intake showed only a trend for associations (HR 1.60; 95% CI 0.90 to 2.84, p=0.106) (online supplementary figure 2). There were associations of FIP and individual components of the primary outcome (all-cause death and HF readmission within 1 year; online supplementary figure 3A). In total, 23 patients died during the 1-year follow-up, including 14 patients in the inadequate FIP group and nine patients in the adequate FIP group. Inadequate FIP was not associated with all-cause mortality within 1 year (HR 1.46; 95% CI 0.60 to 3.57; p=0.409). In contrast, 48 patients were readmitted to the hospital for worsening HF within 1 year, including 32 patients from the inadequate FIP group and 16 patients from the adequate FIP group. Notably, patients from the inadequate FIP group were more likely to be readmitted to the hospital due to worsening HF; however, this was not statistically significant (HR 1.80; 95% CI 0.91 to 3.55; p=0.093). A sensitivity analysis using a different FI cut-off (90%) showed similar results concerning the main result, indicating that inadequate FIP was significantly associated with the primary outcome (HR 1.84; 95% CI 1.05 to 3.23; p=0.033) (online supplementary figure 3B). Finally, subgroup analyses showed that the inadequate FIP group was consistently more likely to have a poor prognosis across various subgroups (online supplementary figure 4).

Discussion

In this study, we demonstrated the following main findings: only half of the HHF patients were able to consume all three meals on the day before hospital discharge; patients with inadequate FIP had higher BNP levels at discharge and lower BNP improvement rates during hospitalisation; there was a significant correlation between FI and CFS; inadequate FIP was associated with a higher incidence of death and readmission due to HF within 1 year; the test for the interaction between HFpEF and HFrEF was significant; HFpEF patients with low FI had significantly higher adverse outcomes, but HFrEF patients did not. Therefore, our study provided evidence that FIP might be used as a prognostic indicator for HHF patients, thereby providing a simple and novel risk stratification method for HHF patients.

To the best of our knowledge, no studies have evaluated the association between FIP and the mid-term prognosis for HHF patients. However, several multicentre observational surveys performed in the field of epidemiology have shown that insufficient intake of the provided food was associated with adverse outcomes. Hiesmayr et al demonstrated that decreased FI represented an independent risk factor for hospital mortality of general hospitalised patients.9 Tangvik et al identified decreased FI as a predictor of morbidity and mortality within 1 year among general hospitalised patients.20 Fernandez et al showed an upward trend between decreased FI and higher 30-day mortality among hematology-oncology patients.10 Thibault et al also demonstrated that patients with a poor nutritional status had more healthcare-associated infections than those with normal nutritional status.21 Energy deficit during the first week of admission was associated with an increased proportion of infections for patients who were in the intensive care unit.22 The results of these studies support the conclusion that inadequate FI is associated with a poor prognosis and are in agreement with our findings for HHF patients.

A significant interaction effect was noted for the HF phenotype (HFpEF vs HFrEF). HFpEF is highly heterogeneous and influenced by a range of cardiac and non-cardiac comorbidities (eg, hypertension, diabetes and atrial fibrillation) typically experienced by elderly patients. These comorbidities lead to systematic microvascular inflammation, which adversely affects the adjacent cardiomyocyte through decreased nitric oxide bioavailability, reduced cyclic guanosine monophosphate availability and altered phosphorylation of titin.23 24 Because such systemic microvascular inflammation leads to impaired myocardial energetics and decreased nutritional status,25 low FI might be a stronger predictor for HFpEF patients in our study. Additionally, because of the increasing number of HFpEF patients in the contemporary cardiovascular practice and the neutral results of large-scale, randomised controlled trials that tested conventional HF therapies, the results of this study provide crucial evidence that could lead to guidelines that enable better care for HFpEF patients. On the other hand, the inadequate FIP group was not associated with adverse outcomes in HFrEF patients. As shown in online supplementary tables 1 and 2, HFrEF patients were younger and less frail than HFpEF patients in our cohort. Therefore, the inadequate FI, considered as indicative of frailty for HFrEF patients, might not be the case when compared with that for HFpEF patients. Moreover, the previous studies that evaluated the association between FIP and adverse outcomes were performed among relatively severe condition populations,10 22 suggesting the utility of FIP among HFpEF patients rather than that among HFrEF patients.

Inadequate intake of the main dish showed a significant association with adverse outcomes, whereas inadequate intake of rice was not significantly associated with adverse outcomes. The difference between the main dish and rice may be that rice, a staple food in Japan, is readily consumed by most Japanese, including patients with severe systemic illness. Therefore, analysing the intake of the main dish and rice separately excluded the possible effect of patients’ food preferences, thereby strengthening the utility of FI as a potential prognostic indicator.

The association of inadequate FI with a worse mid-term prognosis observed in our study could be explained by several mechanisms. First, inadequate FI might reflect insufficient congestion reduction. Patients with inadequate FIP had higher BNP levels at discharge and lower BNP improvement rates during hospitalisation than patients with adequate FIP (table 1 and online supplementary figure 5). This suggested that patients in the inadequate FI group might have had persistent clinical or subclinical congestion. From a physiological viewpoint, patients with persistent congestion have pulmonary oedema, which causes difficulty in breathing during meals and intestinal mucosal oedema related to persistent systemic congestion. Persistent intestinal congestion may lead to reduced secretion of ghrelin, a hormone that enhances growth hormone secretion in the pituitary gland, induces hyperphagia and gastrointestinal motility, and has cardioprotective effects from the intestinal tract, resulting in anorexia.26 27 Therefore, inadequate FIP may be a manifestation of persistent subclinical congestion in HHF patients. The main cause of rehospitalisation for HF was reported to be attributable to poor adherence to a low-salt diet28; therefore, it is difficult to control the appropriate salt intake among patients with HF with persistent congestion and inadequate FI. Further intervention, such as postponement of discharge or implementation of additional medication titration, such as furosemide or tolvaptan, could be considered to improve the prognosis. Inadequate FI is also indicative of frailty, as indicated by our finding of a significant correlation between FI and CFS. Frailty is associated with ageing; it is defined as a decreased physiologic and cognitive function resulting in physical and mental vulnerability to stressors.29 30 For elderly patients with HF, frailty increases the risk of adverse health events.31 Moreover, appropriate early intervention, such as cardiac rehabilitation, aerobic exercise, nutrition education and patient education, reversibly improves the functional capacity of frail HF patients.32 Frailty is also an important consideration during the assessment before advanced HF therapies, including ventricular assist device implantation or heart transplantation.33 Our results are important not only for the prognostication of HF patients but also for frailty assessments.

Our findings should be interpreted in the context of several limitations and considerations. First, because this was an observational study, some unmeasured or unmeasurable variables might have influenced the outcomes. Nevertheless, the robustness of our results was confirmed through rigorous statistical analyses, namely, the sensitivity and subgroup analyses. Second, because of the small sample size, some subgroup analyses with statistically non-significant results may have been underpowered. Third, this study was conducted at a single university-based hospital, which might have affected the external validity of the results. Nevertheless, the baseline characteristics between our population and large-scale Japanese registries were very similar,2 suggesting that our results could be generalised across Japan. Additionally, although hospital meals differ between countries and cultures, FI is universally representative of the systemic status, and various studies of FI have been performed worldwide.9 10 12 15 20–22 Fourth, the cause of reduced FIP was not examined in this study. Factors, such as patients’ food preference as well as the lack of FI and patients’ unwillingness or inability to consume food (eg, due to malignancies), might have affected their FI. Fifth, although the required calorie intake varies with many factors (eg, age, sex, BMI and activities of daily living), we could not examine the individual adequate calorie intake in this study. However, the Harris-Benedict equation was used to estimate basal energy expenditure of individuals adjusted for height, weight, age and sex, and hospital meals were optimised for individual patients.34 Sixth, we could not examine the correlation between FI and the data regarding the physical examination and chest X-ray at discharge because these data were not collected in our database. However, as an alternative measure, we have investigated the association of inadequate FIP with BNP levels at discharge and BNP change rates during hospitalisation, as BNP is shown to be better surrogates for congestion.35 36 Finally, we investigated FIP only on the day before discharge, and changes in FIP during the hospitalisation may have different implications.

In conclusion, inadequate FI by HHF patients is associated with a higher incidence of all-cause mortality or HF readmission within 1 year. Therefore, monitoring FI may be useful for predicting and stratifying risk for HHF patients because it is routinely recorded, simple to perform and economical.

References

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Footnotes

  • Contributors The author contributions are as follows: Planning and conducting the research: TY, SS, YS and SK. Reporting of the work: TY, SS and YS. Critical revision of the manuscript for important intellectual content: MK, TK, KI, KF and PAH.

  • Funding This work was supported by a grant from the Japan Agency for Medical Research and Development (201439013C (SK)), Health Labor Sciences Research Grant (14528506; (SK)), a Grant-Aid for Scientific Research (KAKENHI, 18K08056 (SK)) and a Grant-in-Aid for Young Scientists (JPSS KAKENHI, 18K15860 (YS)).

  • Competing interests SK reports investigator-initiated grant funding from Bayer and Daiichi Sankyo. The other authors declare no conflict of interest.

  • Patient consent for publication Not required.

  • Ethics approval The study protocol was approved by the Keio University Institutional Review Board, and the research was conducted in accordance with the Declaration of Helsinki.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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