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Original research
Aetiological and morphological spectrum of cardiomyopathies in French Guiana: a retrospective study
  1. Paul Leménager1,
  2. Yves-Kenol Franck2,
  3. Florine Corlin1,
  4. Nicolas Bouscaren1,
  5. Mathieu Nacher1 and
  6. Antoine Adenis1
  1. 1CIC INSERM 1424, Centre Hospitalier Andree Rosemon, Cayenne, French Guiana
  2. 2Service de Cardiologie, Centre Hospitalier Andree Rosemon, Cayenne, French Guiana
  1. Correspondence to Professor Mathieu Nacher; mathieu.nacher66{at}gmail.com

Abstract

Introduction Cardiomyopathies are a heterogeneous heart diseases group in terms of morphology and aetiology. Hypothesising a tropical specificity and given an absence of data in French Guiana, the primary objective of our study was to describe morphologies and aetiologies of cardiomyopathies observed at Cayenne General Hospital.

Methods A cross-sectional study was conducted in Cayenne Hospital from 1 January 2009 to 1 June 2014 in the hospital database. Only patients with the definition of the European Society of Cardiology (ESC) were included, based on the first transthoracic ultrasonography found during the study period. Medical files were consulted.

Results With 182 patients included, the prevalence of cardiomyopathies among heart diseases was estimated at 4.3% (95% CI 3.7% to 4.9%). Twelve patients had a familial or genetic aetiology (6.6%) and 170 a non-familial or non-genetic aetiology (93.4%). The morphological spectrum was: dilated for 114 patients (62.6%), hypertrophic for 27 (14.8%), unclassified for 1 (0.5%) and non-classifiable for 13 (7.1%). This group was constituted of patients with a systolic and/or diastolic functional impairment without morphological abnormality. The aetiological spectrum found 184 aetiologies including: 70.9% undetermined, 8.7% infectious (with 6.5% chagasic and 0.5% related with human immunodeficiency virus) and 6.0% with toxins.

Conclusions Cardiomyopthies are a common and severe clinical problem. The frequency of infectious aetiologies and dilated impairment are arguments for cardiomyopathies with tropical particularities. However, the preponderance of undetermined aetiologies justifies the development of further research programmes.

  • cardiomyopathy dilated
  • cardiomyopathy hypertrophic
  • chagas' disease
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Footnotes

  • Contributors PL and AA planned the study, PL, NB, FC and KF conducted the study; PL wrote the initial draft; AA and MN edited the initial draft. AA is the article guarantor.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Hospital Ethical committee (n°1–2016 V1) and Commission Nationale Informatique et Libertés (CNIL N° 1959321). The study was retrospective. For each included patient, as required by French regulations, we enquired whether the patient objected to us consulting the medical files using an individual phone call. When the patient was lost to follow-up or had died, we considered that there was no opposition, as required by French law we had attempted to contact patients to seek non-opposition.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. Data may be requested at cicec@ch-cayenne.fr. Prior to this, clearance to transfer data must be obtained from the commission nationale informatique et libertés 3 Place de Fontenoy - TSA 80715 - 75334 PARIS CEDEX 07.

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