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Original research article
Simple renal cysts and bovine aortic arch: markers for aortic disease
  1. Adam J Brownstein1,2,
  2. Syed Usman Bin Mahmood1,
  3. Ayman Saeyeldin1,
  4. Camilo Velasquez Mejia1,
  5. Mohammad A Zafar1,
  6. Yupeng Li3,
  7. John A Rizzo1,4,5,
  8. Neera K Dahl6,
  9. Young Erben1,7,
  10. Bulat A Ziganshin1,8 and
  11. John A Elefteriades1
  1. 1 Aortic Institute at Yale-New Haven Hospital, Yale School of Medicine, New Haven, Connecticut, USA
  2. 2 Department of Medicine, Johns Hopkins Hospital and Johns Hopkins School of Medicine, Baltimore, MD, USA
  3. 3 Department of Political Science and Economics, Rowan University, Glassboro, New Jersey, USA
  4. 4 Department of Economics, Stony Brook University, Stony Brook, New York, USA
  5. 5 Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, New York, USA
  6. 6 Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
  7. 7 Section of Vascular and Endovascular Surgery, Yale School of Medicine, New Haven, Connecticut, USA
  8. 8 Department of Surgical Diseases No 2, Kazan State Medical University, Kazan, Russia
  1. Correspondence to Dr Adam J Brownstein; abrowns3{at}jhmi.edu

Abstract

Objective This study aimed to assess the prevalence of thoracic aortic disease (TAD) and abdominal aortic aneurysms (AAA) among patients with simple renal cyst (SRC) and bovine aortic arch (BAA).

Methods Through a retrospective search for patients who underwent both chest and abdominal CT imaging at our institution from 2012 to 2016, we identified patients with SRC and BAA and propensity score matched them to those without these features by age, gender and presence of hypertension, hyperlipidaemia, diabetes and chronic kidney disease.

Results Of a total of 35 498 patients, 6366 were found to have SRC. Compared with the matched population without SRC, individuals with SRC were significantly more likely to have TAD (10.1% vs 3.9%), ascending aortic aneurysm (8.0% vs 3.2%), descending aortic aneurysm (3.3% vs 0.9%), type A aortic dissection (0.6% vs 0.2%), type B aortic dissection (1.1% vs 0.3%) and AAA (7.9% vs 3.3%). The 920 patients identified with BAA were significantly more likely to have TAD (21.8% vs 4.5%), ascending aortic aneurysm (18.4% vs 3.2%), descending aortic aneurysm (6.5% vs 2.0%), type A aortic dissection (1.4% vs 0.4%) and type B aortic dissection (2.4% vs 0.7%) than the matched population without BAA. SRC and BAA were found to be significantly associated with the presence of TAD (OR=2.57 and 7.69, respectively) and AAA (OR=2.81 and 2.56, respectively) on multivariable analysis.

Conclusions This study establishes a substantial increased prevalence of aortic disease among patients with SRC and BAA. SRC and BAA should be considered markers for aortic aneurysm development.

  • thoracic aortic aneurysm
  • abdominal aortic aneurysm
  • simple renal cysts
  • bovine aortic arch
  • thoracic aortic dissection

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Footnotes

  • Patient consent for publication Not required.

  • Contributors AJB, SUBM, AS, CVM, MAZ, NKD, YE, BAZ and JAE all contributed to the planning, conduct and reporting of the work described in the article. YL and JAR contributed to the statistical analysis of the reported data. AJB and JAE are responsible for the overall content as guarantors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval Yale Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.