Article Text

PDF

Original research article
The prognostic value of sST2 and galectin-3 considering different aetiologies in non-ischaemic heart failure
  1. David Binas1,
  2. Hanna Daniel2,
  3. Anette Richter1,
  4. Volker Ruppert1,
  5. Klaus-Dieter Schlüter3,
  6. Bernhard Schieffer1 and
  7. Sabine Pankuweit1
  8. on behalf of the Competence Network Heart Failure
  1. 1Department of Internal Medicine and Cardiology, Philipps-University Marburg, Marburg, Germany
  2. 2Institute for Medical Biometry and Epidemiology, Philipps-University Marburg, Marburg, Germany
  3. 3Institute of Physiology, Justus-Liebig-University Giessen, Giessen, Germany
  1. Correspondence to Dr Sabine Pankuweit; pankuwei{at}staff.uni-marburg.de

Abstract

Objective Several studies indicate a prognostic value of sST2 and galectin-3 in heart failure (HF). While previous studies focused on ischaemic cause of HF, we investigated the role of sST2 and galectin-3 in patients with non-ischaemic dilated cardiomyopathy (DCM).

Methods sST2 and galectin-3 serum concentrations were measured in 262 subjects with DCM. Survival rates were determined for all-cause mortality (ACM) and cardiac mortality (CM).

Results In a univariate model, sST2 as a continuous variable was a predictor of ACM (HR 1.05; 95% CI 1.03 to 1.07, P<0.001) and CM (HR 1.03; 95% CI 1.00 to 1.06, P=0.040). In the subgroup of patients with inflammatory and/or viral DCM (DCMi⋎viral), the endpoints ACM (HR 1.10; 95% CI 1.05 to 1.17, P<0.001) and CM (HR 1.10; 95% CI 1.02 to 1.18, P=0.013) were significant. In the subgroup of patients with idiopathic DCM, the endpoint ACM (HR 1.04; 95% CI 1.01 to 1.07, P=0.019) was significant. In a multivariate model, the prognostic value of the sST2 main group remained intact for ACM (HR 1.04; 95% CI 1.02 to 1.07, P=0.003).

Univariate and multivariate analysis of galectin-3 as continuous variable did not show any significant result. However, in a quartile model, intermediate values of galectin-3 were significantly associated with a lower event rate of ACM and CM.

Conclusion The study revealed that sST2 predicts ACM and CM in patients with non-ischaemic HF and could be useful especially in patients with inflammatory background. Our findings that intermediate levels of galectin-3 allow for better prognosis were new and different to other investigations.

Trial registration number NCT03090425; Results.

  • sST2
  • soluble ST2
  • Galectin-3
  • Heart failure
  • Dilated Cardiomyopathy

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

View Full Text

Statistics from Altmetric.com

Footnotes

  • Contributors DB performed the ELISA analyses, completed the data and wrote the manuscript. HD performed the statistics. AR and VR included the patients and data, K-DSU and BS wrote the manuscript. SP initiated the investigations, included patients and patients data, wrote and revised the manuscript.

  • Competing interests None declared.

  • Patient consent Detail has been removed from this case description/these case descriptions to ensure anonymity. The editors and reviewers have seen the detailed information available and are satisfied that the information backs up the case the authors are making.

  • Ethics approval Ethics committee of the Medical Faculty of the Philipps-University Marburg.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement There are no additional data available for this paper.

  • Presented at Parts of the data were presented as poster during the Annual meeting of the European Society of Cardiology in Rome 2016 and published as abstract as follows: Eur Heart J, 2016; 37(Suppl_1): 599–983.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.