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Original research article
Predictors and prognostic value of left atrial remodelling after acute myocardial infarction
  1. Kasper Kyhl1,2,
  2. Niels Vejlstrup1,
  3. Jacob Lønborg1,
  4. Marek Treiman2,
  5. Kiril Aleksov Ahtarovski1,
  6. Steffen Helqvist1,
  7. Henning Kelbæk1,
  8. Lene Holmvang1,
  9. Erik Jørgensen1,
  10. Kari Saunamäki1,
  11. Helle Søholm1,
  12. Mads J Andersen1,
  13. Jacob E Møller1,
  14. Peter Clemmensen1 and
  15. Thomas Engstrøm1
  1. 1Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
  2. 2Department of Biomedical Sciences, Copenhagen University, Copenhagen, Denmark
  1. Correspondence to Dr Kasper Kyhl; kasperkyhl{at}


Purpose Left atrial (LA) volume is a strong prognostic predictor in patients following ST-segment elevation myocardial infarction (STEMI). However, the change in LA volume over time (LA remodelling) following STEMI has been scarcely studied. We sought to identify predictors for LA remodelling and to evaluate the prognostic importance of LA remodelling.

Methods This is a subgroup analysis from a randomised clinical trial that evaluated the cardioprotective effect of exenatide treatment. A total of 160 patients with STEMI underwent a cardiovascular MR (CMR) 2 days after primary angioplasty and a second scan 3 months later. LA remodelling was defined as changes in LA volume or function from baseline to 3 months follow-up. Major adverse cardiac events were registered after a median of 5.2 years.

Results Adverse LA minimum volume (LAmin) remodelling was correlated to the presence of hypertension, larger infarct size by CMR, higher peak troponin T, larger area at risk and adverse left ventricular (LV) remodelling. LA maximum volume (LAmax) remodelling was correlated to larger infarct size by CMR, higher peak troponin T, larger area at risk, larger LV mass, impaired LV function and adverse LV remodelling. Kaplan-Meier and Log Rank analyses showed that patients in the highest tertiles of LAmin or LAmax remodelling are at higher risk (0.030 and p=0.018).

Conclusions After a myocardial infarction, LA remodelling reflects a parallel ventricular-atrial remodelling. Infarct size is a major determinant of LA remodelling following STEMI and adverse LA remodelling is associated with an unfavourable prognosis.


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