User profiles for "author:Soumeya Bekri"

Soumeya BEKRI

Professor of Medical Biochemistry and Molecular Biology - Rouen University
Verified email at chu-rouen.fr
Cited by 18581

[HTML][HTML] Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations

A Tebani, C Afonso, S Marret, S Bekri - International journal of molecular …, 2016 - mdpi.com
The rise of technologies that simultaneously measure thousands of data points represents
the heart of systems biology. These technologies have had a huge impact on the discovery …

[HTML][HTML] Clinical metabolomics: the new metabolic window for inborn errors of metabolism investigations in the post-genomic era

A Tebani, L Abily-Donval, C Afonso, S Marret… - International journal of …, 2016 - mdpi.com
Inborn errors of metabolism (IEM) represent a group of about 500 rare genetic diseases with
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …

[HTML][HTML] Paving the way to precision nutrition through metabolomics

A Tebani, S Bekri - Frontiers in nutrition, 2019 - frontiersin.org
Nutrition is an interdisciplinary science that studies the interactions of nutrients with the body
in relation to maintenance of health and well-being. Nutrition is highly complex due to the …

Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH

S Bekri, P Gual, R Anty, N Luciani, M Dahman… - Gastroenterology, 2006 - Elsevier
Backgrounds & Aims: Hepcidin is an acute-phase response peptide. We have investigated
the possible involvement of hepcidin in massive obesity, a state of chronic low-grade …

Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation

S Bekri, G Kispal, H Lange, E Fitzsimons… - Blood, The Journal …, 2000 - ashpublications.org
The human protein ABC7 belongs to the adenosine triphosphate-binding cassette
transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the …

Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation

C Brasse–Lagnel, Z Karim, P Letteron, S Bekri, A Bado… - Gastroenterology, 2011 - Elsevier
Backgrounds & Aims The mechanism by which hepcidin regulates iron export from
macrophages has been well established and is believed to involve degradation of …

The inflammatory C-reactive protein is increased in both liver and adipose tissue in severely obese patients independently from metabolic syndrome, Type 2 diabetes …

R Anty, S Bekri, N Luciani, MC Saint-Paul… - Official journal of the …, 2006 - journals.lww.com
OBJECTIVE C-Reactive Protein (CRP), a nonspecific marker of inflammation that is
moderately elevated in obesity, metabolic syndrome (MS), and type 2 diabetes, has been …

Disruption of autophagy at the maturation step by the carcinogen Lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal …

E Corcelle, M Nebout, S Bekri, N Gauthier, P Hofman… - Cancer research, 2006 - AACR
Macroautophagy (hereafter referred to as autophagy) has emerged as a key tumor
suppressor pathway. During this process, the cytosolic constituents are sequestered into …

Autophagosome maturation is impaired in Fabry disease

M Chévrier, N Brakch, L Céline, D Genty, Y Ramdani… - Autophagy, 2010 - Taylor & Francis
Fabry disease is a lysosomal storage disorder (LSD) caused by a deficiency in α-
galactosidase A. The disease is characterized by severe major organ involvement, but the …

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia

C Michot, L Hubert, NB Romero, A Gouda… - Journal of inherited …, 2012 - Springer
Background Recessive LPIN1 mutations were identified as a cause of severe
rhabdomyolysis in pediatric patients. The human lipin family includes two other closely …