[HTML][HTML] Combination therapy with an SGLT2 inhibitor as initial treatment for type 2 diabetes: a systematic review and meta-analysis

TY Milder, SL Stocker, C Abdel Shaheed… - Journal of clinical …, 2019 - mdpi.com
Background: Guidelines differ with regard to indications for initial combination
pharmacotherapy for type 2 diabetes. Aims: To compare the efficacy and safety of (i) sodium …

Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection

D Adlam, TM Olson, N Combaret, JC Kovacic… - Journal of the American …, 2019 - jacc.org
Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized
cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged …

Spontaneous coronary artery dissection and fibromuscular dysplasia: vasculopathies with a predilection for women

SE Iismaa, S Hesselson, L McGrath-Cadell… - Heart, Lung and …, 2021 - Elsevier
The burden of cardiovascular disease in women is being increasingly appreciated.
Nevertheless, both clinicians and the general public are largely unaware that cardiovascular …

Spontaneous coronary artery dissection: insights on rare genetic variation from genome sequencing

KJ Carss, AA Baranowska, J Armisen… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: Spontaneous coronary artery dissection (SCAD) occurs when an epicardial
coronary artery is narrowed or occluded by an intramural hematoma. SCAD mainly affects …

Outcomes of patients with spontaneous coronary artery dissection

L McGrath-Cadell, P McKenzie, S Emmanuel… - Open …, 2016 - openheart.bmj.com
Background Spontaneous coronary artery dissection (SCAD) is an uncommon but serious
condition presenting as an acute coronary syndrome (ACS) or cardiac arrest. The …

Exploring the genetic architecture of spontaneous coronary artery dissection using whole-genome sequencing

I Tarr, S Hesselson, SE Iismaa, E Rath… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary
syndrome that predominantly affects women. Its pathophysiology remains unclear but …

[HTML][HTML] Accuracy of vascular tortuosity measures using computational modelling

V Kashyap, R Gharleghi, DD Li, L McGrath-Cadell… - Scientific reports, 2022 - nature.com
Severe coronary tortuosity has previously been linked to low shear stresses at the luminal
surface, yet this relationship is not fully understood. Several previous studies considered …

The mystery and enigma of spontaneous coronary artery dissection

RM Graham, L McGrath-Cadell… - Heart, Lung and …, 2018 - heartlungcirc.org
First described in 1931 [1], spontaneous coronary artery dissection (SCAD) is a non-
atheromatous disease of the coronary arteries that presents as an acute coronary syndrome …

Polygenic Risk in Families With Spontaneous Coronary Artery Dissection

I Tarr, S Hesselson, M Troup, P Young… - JAMA …, 2024 - jamanetwork.com
Importance Spontaneous coronary artery dissection (SCAD) is a poorly understood cause of
acute coronary syndrome that predominantly affects women. Evidence to date suggests a …

Sex-Specific Variances in Anatomy and Blood Flow of the Left Main Coronary Bifurcation: Implications for Coronary Artery Disease Risk

R Gharleghi, M Zhang, D Adikari… - arXiv preprint arXiv …, 2023 - arxiv.org
Studies have shown marked sex disparities in Coronary Artery Diseases (CAD)
epidemiology, yet the underlying mechanisms remain unclear. We explored sex disparities …