User profiles for "author:James, E Clark"

James E. Clark

King's College London
Verified email at kcl.ac.uk
Cited by 8737

Bioactivity and pharmacological actions of carbon monoxide-releasing molecules

R Motterlini, BE Mann, TR Johnson… - Current …, 2003 - ingentaconnect.com
Carbon monoxide (CO) is a resourceful gas as recent advances in the area of cell signaling
are revealing an unexpected physiological role for CO in the cardiovascular, immune and …

[HTML][HTML] Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who …

JE Clark - Journal of Diabetes & Metabolic Disorders, 2015 - Springer
There are number of means of methods to alter body composition, and metabolic issues,
available for the adult who is overfat. The following is a systematic review and meta-analysis …

What is mood? A computational perspective

JE Clark, S Watson, KJ Friston - Psychological medicine, 2018 - cambridge.org
The neurobiological understanding of mood, and by extension mood disorders, remains
elusive despite decades of research implicating several neuromodulator systems. This …

Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities

R Motterlini, JE Clark, R Foresti… - Circulation …, 2002 - Am Heart Assoc
Carbon monoxide (CO) is generated in living organisms during the degradation of heme by
the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible …

Cardioprotective actions by a water-soluble carbon monoxide–releasing molecule

JE Clark, P Naughton, S Shurey, CJ Green… - Circulation …, 2003 - Am Heart Assoc
Carbon monoxide, which is generated in mammals during the degradation of heme by the
enzyme heme oxygenase, is an important signaling mediator. Transition metal carbonyls …

Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction

JE Clark, R Foresti, P Sarathchandra… - American Journal …, 2000 - journals.physiology.org
Bilirubin is a potent antioxidant generated intracellularly during the degradation of heme by
the enzyme heme oxygenase. The purpose of this study was to determine the role of …

Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule

R Foresti, J Hammad, JE Clark… - British journal of …, 2004 - Wiley Online Library
Carbon monoxide (CO), one of the end products of heme catabolism by heme oxygenase,
possesses antihypertensive and vasodilatory characteristics. We have recently discovered …

Metal carbonyls: a new class of pharmaceuticals?

TR Johnson, BE Mann, JE Clark… - Angewandte Chemie …, 2003 - Wiley Online Library
It is now established that NO is a messenger molecule in mammals despite its high toxicity.
As NO+ and CO are isoelectronic, it should not be unexpected that CO could also have a …

Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress

JE CLARK, R FORESTI, CJ GREEN… - Biochemical …, 2000 - portlandpress.com
The inducible isoform of haem oxygenase (HO-1) has been proposed as an effective system
to counteract oxidant-induced cell injury. In several circumstances, this cytoprotective effect …

Heme oxygenase-1–derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo

R Motterlini, A Gonzales, R Foresti, JE Clark… - Circulation …, 1998 - Am Heart Assoc
The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2)
isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO …