Here we discuss recent advances in understanding the biochemical, immunologic, and
genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis …

During pre-mRNA splicing, exons in the primary transcript are precisely connected to
generate an mRNA. Intron lariat RNAs are formed as by-products of this process. In addition …

Olprinone is a newly developed phosphodiesterase III inhibitor characterized by several
properties. First, olprinone has positive inotropic and vasodilator actions and improves …

IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of
galactose-deficient IgA1 and a glycan-specific IgG antibody. These immune complexes …

Environmental pathogens are suspected to aggravate renal injury in IgA nephropathy
(IgAN), but neither underlying mechanisms nor specific exogenous antigens have been …

Besides linear RNAs, pre-mRNA splicing generates three forms of RNAs: lariat introns, Y-
structure introns from trans-splicing, and circular exons through exon skipping. To study the …

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

Galactose-deficient IgA1 has been proposed as an important effector molecule in IgA
nephropathy (IgAN). We previously showed that the galactose-deficient IgA1-specific …

Aberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA
nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region …

Alternative splicing is one of the central mechanisms that regulate eukaryotic gene
expression. Here we report a tissue‐specific RNA‐binding protein, Fox‐1, which regulates …