SERUM CHOLESTEROL AND CANCER IN THE NHANES I EPIDEMIOLOGIC FOLLOWUP STUDY
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PCSK9 and cancer: Rethinking the link
2021, Biomedicine and PharmacotherapyCitation Excerpt :Additionally, there was correlation between low cholesterol levels and decreased risk of prostate cancer. However, no significant association was observed between total cholesterol levels and risk of colorectal cancer [16], while other cohort studies in United States [271–273] and Scotland [274] indicated a reverse correlation. Several mechanisms have been proposed for decreased cholesterol occurring during malignancies including the impact of tumor necrosis factor on cholesterol metabolism [275] and the tendency of cancerous cells to increase LDLR activity resulting in high LDL-C uptake [32].
The first multi-zoo application of an allostatic load index to western lowland gorillas (Gorilla gorilla gorilla)
2018, General and Comparative EndocrinologyCitation Excerpt :Cholesterol in gorillas is generally higher than 200 mg/dL, which is higher than humans on average (Baitchman et al., 2006; Schmidt et al., 2006), and Schmidt and colleagues reported in 2006 that 41% of western lowland gorillas housed in zoos were diagnosed with CVD. However, several studies in humans instead show an inverse relationship between cholesterol and mortality risk (Forette et al., 1989; Harris et al., 1992; Horwich et al., 2002; Isles et al., 1989; Iso et al., 1989; Kark et al., 1980; Kronmal et al., 1993; Muldoon et al., 1993; Schatzkin et al., 1987; Schatz et al., 2001; Weverling-Rijnsburger et al., 1997). Triglycerides were significantly associated with allostatic load in gorillas at the Louisville Zoo and in both pooled samples, although there were no data on triglycerides for Omaha gorillas.
The complex interplay between cholesterol and prostate malignancy
2011, Urologic Clinics of North AmericaCitation Excerpt :The conclusions of this early study were buttressed by several additional population studies that showed excess cancers in the cohorts with the lowest cholesterol. We have reviewed 52 population studies9–60 that reported on cholesterol and total cancer incidence and/or mortality that were published from 1972 to 2009. In total, these reports cover 79.5 million men and women ages 15 to 99 years (average 38–63 years) from Finland, Yugoslavia, the United States, New Zealand, Italy, France, Japan, China, Scotland, England, Norway, Israel, Australia, and Sweden.
Statins and risk of cancer: A retrospective cohort analysis of 45,857 matched pairs from an electronic medical records database of 11 million adult Americans
2011, Journal of the American College of CardiologyCitation Excerpt :Duration of statin use could also be assessed in this context. Last, it would be of interest to use the GE Centricity database to further investigate LDL levels and cancer risk, especially because the treatment targets for serum lipids are set even lower (37) to levels (e.g., LDL <100 mg/dl) that have been implicated in previous cancer association studies (18,38–40). This EMR database analysis of more than 91,000 U.S. adults with complete clinical datasets who were propensity matched with an average of 4.6 years of follow-up, demonstrated no statistically significant increased risk of cancer associated with statins.