In search of blood tests for thoracic aortic diseases

Ann Thorac Surg. 2010 Nov;90(5):1735-42. doi: 10.1016/j.athoracsur.2010.04.111.

Abstract

A number of new diagnostic screening tools have been developed for the assessment of acute and chronic diseases of the thoracic aorta. Although standardized blood-based tests capable of detecting individuals at risk for aortic aneurysm and dissection disease are not yet available, our current knowledge is expanding at a rapid rate and the future is very promising. In this review, an update of the contemporary knowledge on blood tests for detecting thoracic aortic diseases in both preclinical and clinical settings is provided, offering the potential to predict adverse aortic events, such as enlargement, rupture, and dissection.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / analysis
  • Aortic Aneurysm, Abdominal / blood
  • Aortic Aneurysm, Abdominal / diagnosis
  • Aortic Aneurysm, Thoracic / blood
  • Aortic Aneurysm, Thoracic / diagnosis*
  • Aortic Dissection / blood
  • Aortic Dissection / diagnosis*
  • Calcium-Binding Proteins / blood
  • Calponins
  • Cytokines / blood
  • Fibrin Fibrinogen Degradation Products / analysis
  • Hepatocyte Growth Factor / blood
  • Humans
  • Matrix Metalloproteinases / blood
  • Microfilament Proteins / blood
  • Myosin Heavy Chains / blood

Substances

  • Acute-Phase Proteins
  • Calcium-Binding Proteins
  • Cytokines
  • Fibrin Fibrinogen Degradation Products
  • Microfilament Proteins
  • fibrin fragment D
  • Hepatocyte Growth Factor
  • Matrix Metalloproteinases
  • Myosin Heavy Chains