Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease

Raed A Aqel; Gilbert J Zoghbi; James R Trimm; Shawn A Baldwin; Ami E Iskandrian

doi:10.1016/j.amjcard.2003.10.017

Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease

Am J Cardiol. 2004 Feb 1;93(3):343-6. doi: 10.1016/j.amjcard.2003.10.017.

Authors

Raed A Aqel¹, Gilbert J Zoghbi, James R Trimm, Shawn A Baldwin, Ami E Iskandrian

Affiliation

¹ Division of Cardiovascular Disease, Birmingham's Veterans Affair Medical Center, and Department of Medicine, University of Alabama at Birmingham, 35233, USA. raqel@cardio.dom.uab.edu

PMID: 14759387
DOI: 10.1016/j.amjcard.2003.10.017

Abstract

It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors. We studied the effect of caffeine on adenosine-induced myocardial hyperemia measured by fractional flow reserve after intracoronary adenosine administration. Fractional flow reserve was not affected by intravenous caffeine infusion at a dose that was comparable to oral consumption.

Publication types

Clinical Trial

MeSH terms

Adenosine / administration & dosage*
Adenosine A2 Receptor Antagonists*
Adult
Caffeine / administration & dosage*
Coronary Artery Disease / physiopathology*
Hemodynamics / drug effects
Humans
Hyperemia / physiopathology*
Infusions, Intravenous
Injections, Intra-Arterial
Male
Middle Aged
Pilot Projects
Vasodilator Agents / administration & dosage*

Substances

Adenosine A2 Receptor Antagonists
Vasodilator Agents
Caffeine
Adenosine