Pre-Clinical ResearchDirect Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells
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Key Words
cardiac stem cells
mesenchymal stem cells
myocardial regeneration
paracrine effects
Abbreviations and Acronyms
α-SA
α-sarcomeric actin
AD-MSCs
adipose tissue–derived mesenchymal stem cells
bFGF
basic fibroblast growth factor
BM-MNCs
bone marrow mononuclear cells
BM-MSCs
bone marrow–derived mesenchymal stem cells
CDCs
cardiosphere-derived cells
ELISA
enzyme-linked immunoadsorbent assay
HGF
hepatocyte growth factor
HNA
human nuclear antigen
IGF
insulin-like growth factor
IMDM
Iscove's modified Dulbecco's medium
LV
left ventricular
LVEF
left ventricular ejection fraction
PCR
polymerase chain reaction
SCID
severe combined immunodeficiency
SDF
stromal cell–derived factor
TUNEL
terminal deoxynucleotidyl transferase dUTP nick end labeling
VEGF
vascular endothelial growth factor
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This study was supported by the National Institutes of Health (HL095203) to Capricor, Inc., by the National Institutes of Health (U54 HL081028) to Dr. E. Marbán, and by the Cedars-Sinai Board of Governors Heart Stem Cell Center. Dr. E. Marbán is the Mark S. Siegel Family Professor of the Cedars-Sinai Medical Center. Dr. E. Marbán and Dr. L. Marbán hold founders' equity in Capricor, Inc. Drs. Smith, Blusztajn, Terrovitis, and L. Marbán are employed by Capricor, Inc. Drs. Malliaras and Terrovitis are consultants of Capricor, Inc.
All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Li, Cheng, and Malliaras contributed equally to this work.
Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.