ReviewIn Search of Blood Tests for Thoracic Aortic Diseases
Section snippets
Material and Methods
For this review, we queried the PubMed and the Cochrane Library CENTRAL and EMBASE databases using the key words aortic aneurysm, aortic dissection, diagnosis, and biomarkers.
Conclusions
The rapidly aging patient population in Western societies and the resultant increase in aortic disease, coupled with the unpredictably virulent clinical nature of aortic aneurysm, cry out for advances in biomarker detection of aneurysm activity. Several biochemical markers potentially may be predictive of clinical disease (Table 1). Practical limitations to implementation of biomarker-based diagnosis and prediction relate to the need that potential candidate assays be readily employable in
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Epidemiology of thoracoabdominal aortic aneurysms
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2019, Canadian Journal of CardiologyEctopic Expression of PCSK9 by Smooth Muscle Cells Contributes to Aortic Dissection
2018, Annals of Vascular SurgeryPotential biomarkers for early diagnosis of acute aortic dissection
2015, Heart and Lung: Journal of Acute and Critical CareCitation Excerpt :Imaging modalities have been the standard of care in diagnosis of AAD, however every study has its pros and cons. Recently, some progress has been achieved on the role of biomarkers for a rapid diagnosis of early AAD.10 In this study, a combination of any two biomarkers of smMHC, sELAF, PC1 and D-dimer showed a significant diagnostic value for the early identification of AAD.
D-dimer levels remain elevated in acute aortic dissection after 24 h
2014, Journal of Surgical ResearchCitation Excerpt :D-dimers are cross-linked fibrin derivatives that result from the degradation of fibrin during coagulopathy in the false lumen of the dissected aorta. D-dimer levels are commonly used to rule out acute deep venous thrombus disease [11,15,16]. In addition, D-dimer levels may reflect the disease course and prognosis of AAD and distinguish acute (present for <14 d) from chronic (present for ≥14 d) dissection [17].
Morphologic predictors of aortic dilatation in type B aortic dissection
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