Acta Pharmaceutica Sinica B

Acta Pharmaceutica Sinica B

Volume 5, Issue 5, September 2015, Pages 367-377
Acta Pharmaceutica Sinica B

REVIEW
Hydrogen sulfide prodrugs—a review

https://doi.org/10.1016/j.apsb.2015.06.004Get rights and content
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Abstract

Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.

Graphical abstract

Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.

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KEY WORDS

Hydrogen sulfide (H2S)
Gasotransmitters
H2S prodrugs
H2S-hybrid nonsteroidal anti-inflammatory drugs
Controllable H2S prodrugs
Hydrolysis-based H2S prodrugs

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Peer review under responsibility of Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association.

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