Coronary artery diseaseUsefulness of Coronary Computed Tomography Angiography to Predict Mortality and Myocardial Infarction Among Caucasian, African and East Asian Ethnicities (from the CONFIRM [Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter] Registry)
Section snippets
Methods
The Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter (CONFIRM) registry is an ongoing, prospective, international, multicenter registry designed to evaluate the relation of coronary atherosclerosis and clinical risk factors to adverse outcomes among patients who have undergone at least 64-slice CCTA for clinically referred indications (ClinicalTrials.gov identifier NCT01443637).10 The rationale and design of the CONFIRM registry have been previously
Results
Ethnicity data were coded for 16,451 patients at 11 sites (7 countries). The mean age was 58 ± 12 years (55% men), and patients were followed over a median of 2.0 years (interquartile range 1.4 to 3.2 years). Middle Eastern (n = 67), South Asian (n = 72), Hispanic (n = 534), and other (n = 127) ethnicities were each coded during data collection but were excluded because they were individually underpowered for analysis. Baseline demographics are listed in Table 1. Patients were 60.1% Caucasian,
Discussion
CCTA has emerged as an important diagnostic test for the assessment of CAD with increasingly proved prognostic value, but studies published to date contain minimal information regarding the prognostic value of CCTA among different ethnic subgroups.1, 3, 4, 17, 18, 19, 20 Studies using noncontrast computed tomography to detect and quantify calcified atherosclerosis have demonstrated ethnic variations in calcified CAD prevalence and have confirmed the prognostic value of calcium scoring in
Disclosures
Dr. Villines has received speaker's honoraria from Boehringer-Ingelheim, Ingelheim, Germany. Dr. Achenbach has received grant support from Siemens Healthcare, Erlangen, Germany, and Bayer Schering Pharma AG, Berlin, Germany. Dr. Budoff has received speaker's honoraria from GE Healthcare, Milwaukee, Wisconsin. Dr. Cademartiri has received grant support from GE Healthcare and speaker's honoraria from Bracco Diagnostics, Milan, Italy. Dr. Callister is on the speaker's bureau of GE Healthcare. Dr.
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