MiscellaneousComparison of Factors Associated With Coronary Artery Dilation Only Versus Coronary Artery Aneurysms in Patients With Kawasaki Disease
Section snippets
Methods
All patients with KD diagnosed or referred to the Hospital for Sick Children (Toronto, Ontario, Canada) from January 1990 to April 2007 were included. The institutional research ethics board approved the present study, and the requirement for individual patient consent was waived because it was a retrospective study. The records were reviewed for patient demographics, medical history, clinical characteristics at presentation, laboratory investigation findings, medical management, and CA
Results
A total of 1,374 patients (63% men) with KD were diagnosed or referred to the Hospital for Sick Children during the study period. According to our definition, 1,108 patients (81%) had no CA abnormalities, 180 (13%) had CA dilation only, and 86 (6%) had CA aneurysms after KD. The median age at diagnosis was 3.1 years (range 0.2–17.7), with 16% of patients <1 year of age and 6% >9 years of age. A complete presentation (fever ≥5 days and ≥4 classic KD clinical signs) at diagnosis was seen in 75%
Discussion
Our results have delineated the differences in the factors associated with CA dilation only versus CA aneurysms and suggest that CA dilation only and CA aneurysms are part of the same inflammatory process. Previous studies have either considered all CA abnormalities as a single group or have focused solely on identifying the risk factors for giant aneurysms.6, 15 This distinction is important, because it might have implications for the potential for aneurysm regression and long-term cardiac
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Supported in part by the Canadian Imperial Bank of Commerce (CIBC) World Markets Children's Miracle Foundation (Toronto, Ontario, Canada).