Preventive cardiologyFindings from Left Ventricular Strain and Strain Rate Imaging in Asymptomatic Patients With Type 2 Diabetes Mellitus
Section snippets
Methods
A total of 47 patients with type 2 diabetes mellitus were recruited for the present study. The inclusion and exclusion criteria for the diabetic patients have been previously reported.2 In brief, women were not recruited to avoid the possible confounding influences of gender and plasma estrogen levels on lipid metabolism and myocardial triglyceride accumulation. The inclusion criteria for all diabetic patients were (1) type 2 diabetes mellitus diagnosed according to the World Health
Results
The mean age, body mass index, and body surface area was 57.1 ± 6.2 years, 27.0 ± 3.1 kg/m2, and 2.07 ± 0.18 m2, respectively. No significant differences were found between the diabetic patients and controls (Table 1). The median diabetes mellitus diagnosis duration was 4 years (range 1 to 11), and the mean hemoglobin A1c level was 6.4 ± 0.7%. Although no evidence was seen of autonomic neuropathy in the patients with diabetes mellitus, as documented by Ewing's test, the mean heart rate and
Discussion
The results of the present study have demonstrated the presence of subclinical myocardial systolic and diastolic dysfunction in patients with type 2 diabetes mellitus, no diabetic-related complications, and good glycemic control. Despite a normal LV mass, LV volume, and LVEF, the diabetic population showed impairment of LV longitudinal strain and SR but preserved circumferential and radial strain and SR. The presence of diabetes mellitus was an independent predictor of LV longitudinal strain,
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Dr. Bax received grants from Biotronik, Lake Oswego, Oregon; Medtronic, Minneapolis, Minnesota; Boston Scientific, Natick, Massachusetts; Bristol-Myers Squibb Medical Imaging, North Billerica, Massachusetts; St. Jude Medical, St. Paul, Minnesota; GE Healthcare, and Edwards Lifesciences, Irvine, California.