Elsevier

Biochimie

Volume 80, Issue 10, October 1998, Pages 803-806
Biochimie

Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis

https://doi.org/10.1016/S0300-9084(00)88874-4Get rights and content

Abstract

Mitochondrial and cytosolic HMG-CoA synthases are encoded by two different genes. Control of ketogenesis is exerted by transcriptional regulation of mitochondrial HMG-CoA synthase. Fasting, cAMP, and fatty acids increase its transcriptional rate, while refeeding and insulin repress it. Fatty acids increase transcription through peroxisomal proliferator regulatory element (PPRE), to which peroxisome proliferator activated receptor (PPAR) can bind. Other transcription factors such as chicken ovalbumin upstream promoter transcription factor (COUP-TF) and hepatocyte nuclear factor 4 (HNF-4) compete for the PPRE site, modulating the response of PPAR.

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