Elsevier

The Lancet

Volume 365, Issue 9469, 23–29 April 2005, Pages 1484-1486
The Lancet

Research Letters
Aortic wall thickness in newborns with intrauterine growth restriction

https://doi.org/10.1016/S0140-6736(05)66419-7Get rights and content

Summary

Much epidemiological evidence has linked low birthweight with late cardiovascular risk. We measured aortic wall thickness (a marker of early atherosclerosis) by ultrasonography in 25 newborn babies with intrauterine growth restriction and 25 with normal birthweight. Maximum aortic thicknesses were significantly higher in the babies with intrauterine growth restriction (810 μm [SD 113]) than in those without (743 μm [76], p=0·02), more so after adjustment for birthweight (300 μm/kg [45] vs 199 μm/kg [29], p<0·0001). Newborn babies with growth restriction have significant aortic thickening, suggesting that prenatal events might predispose to later cardiovascular risk.

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