Utility of positron emission tomography in predicting cardiac events and survival in patients with coronary artery disease and severe left ventricular dysfunction☆
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Acknowledgements
The investigators thank the technologist of the Kreitchman PET Center for assistance in performing the PET studies, and Robert R. Sciacca, D Eng Sci, for help with statistical analysis.
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Non-invasive imaging in detecting myocardial viability: Myocardial function versus perfusion
2014, IJC Heart and VasculatureCardiac radionuclide imaging to assess patients with heart failure
2014, Seminars in Nuclear MedicineCitation Excerpt :Nevertheless, studies have shown improved detection of viability with metabolic PET vs perfusion SPECT. Rohatgi et al89 found significant viability by PET in approximately 60% of 99 patients with severely reduced LVEF who had been interpreted as having only scar by 201Tl, and revascularization was associated with significantly improved survival compared with medical therapy alone. More recently in the Positron Emission Tomography and Recovery Following Revascularization (PARR)-1 and PARR-2 study series, Beanlands et al90 investigated the use of 18F-FDG-PET to assess viability in patients with severe (LVEF < 35%) ischemic LV dysfunction.
Assessment of myocardial perfusion and viability by Positron Emission Tomography
2013, International Journal of CardiologyCitation Excerpt :A major goal of viability studies is to identify patients with low LVEF who are at the highest clinical risk and in whom revascularization, may offer the greatest survival benefit. Several mostly retrospective studies have shown that 18FDG PET is a valuable tool for risk stratification of patients with LV dysfunction and viable myocardium by revealing significantly worse outcomes for those not undergoing timely revascularization [64–66]. In contrast, there was no apparent benefit from revascularization over medical therapy in the absence of demonstrated myocardial viability.
PET imaging with FDG to guide revascularization in patients with systolic heart failure
2013, Egyptian Heart JournalMyocardial Ischemic Disease: Nuclear
2012, Problem Solving in Radiology: Cardiovascular Imaging
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This study was supported in part by The Jacob and Hilda Blaustein Foundation, Baltimore, Maryland.