Trial designDanish multicenter randomized study on fibrinolytic therapy versus acute coronary angioplasty in acute myocardial infarction: rationale and design of the danish trial in acute myocardial infarction-2 (DANAMI-2)☆
Section snippets
Overview
The planned randomization calls for a total of 1900 patients with suspected ST-elevation acute myocardial infarction to be randomly assigned to receive fibrinolytic therapy or primary angioplasty. The study will include 1100 patients admitted to referral hospitals and 800 patients admitted directly to invasive hospitals. Half of the 1100 patients will immediately be transferred by ambulance to an invasive hospital to be treated with primary angioplasty.
End points
The primary end point was a composite end
Conclusion
DANAMI-2 is a multicenter, randomized, community trial that enrolled 1572 patients with ST-elevation myocardial infarction to determine whether primary angioplasty or fibrinolysis should be the preferred treatment strategy on a community basis.
References (7)
- et al.
Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarctiona quantitative review of 23 randomised trials
Lancet
(2003) - et al.
A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarctionthe Air Primary Angioplasty in Myocardial Infarction study
J Am Coll Cardiol
(2002) - et al.
A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group
N Engl J Med
(1993)
Cited by (101)
Modern Management of ST-Segment Elevation Myocardial Infarction
2020, Current Problems in CardiologyThe impact of recommended percutaneous coronary intervention care on hospital outcomes for interhospital-transferred STEMI patients
2017, American Journal of Emergency MedicineAchieving regionalization through rural interhospital transfer
2015, American Journal of Emergency MedicineCitation Excerpt :Based partly on the effectiveness of developing robust trauma systems [24], STEMI care was regionalized into transfer networks locally to shorten the time to cardiac catheterization—another time-sensitive intervention. Mortality is reduced when percutaneous coronary intervention (PCI) is performed rapidly in STEMI patients [9,25–28], and guidelines recommend this therapy within 90 minutes of presentation [29,30]. In 2000, the Brain Attack Coalition published guidelines to establish Primary Stroke Centers to improve care of patients with acute ischemic stroke [31].
Management and outcomes of ST-elevation myocardial infarction in nursing home versus community-dwelling older patients: A propensity matched study
2014, Journal of the American Medical Directors Association
- ☆
Supported by grants from the Danish Heart Foundation, The Danish Medical Research Council, Astra-Zeneca, Bristol-Myers Squibb, Cordis, a Johnson & Johnson Company, Pfizer, Pharmacia-Upjohn, Boehringer Ingelheim and Logic I/S Guerbet SA.