Clinical study
High density lipoprotein as a protective factor against coronary heart disease: The Framingham study

https://doi.org/10.1016/0002-9343(77)90874-9Get rights and content

Abstract

Lipid and lipoproiein values, including fasting triglycerides and high density lipoproteins (HDL), low density llpoproteins (LDL) and total cholesterol levels, were obtained on 2,815 men and women aged 49 to 82 years chiefly between 1969 and 1971 at Framingham. In the approximately four years following the characterization of lipids, coronary heart disease developed in 79 of the 1,025 men and 63 of the 1,445 women free of coronary heart diseases. At these older ages the major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease (p < 0.001) in either men or women. This lipid was associated with each major manifestation of coronary heart disease. These associations were equally significant even when other lipids and other standard risk factors for coronary heart disease were taken into consideration. A weaker association with the incidence of coronary heart disease (p < 0.05) was observed for LDL cholesterol. Triglycerides were associated with the incidence of coronary heart disease only in women and then only when the level of other lipids was not taken into account. At these ages total cholesterol was not associated with the risk of coronary heart disease.

References (37)

  • G Bondjers et al.

    HDL dependent elimination of cholesterol from human arterial tissue

  • DS Fredrickson et al.

    Familial lipoprotein deficiency (Tangier disease)

  • T Kaschinsky et al.

    Effects of high density lipoprotein (HDL) on low density lipoprotein (LDL) metabolism by pig smooth muscle cells (SMC)

    Circulation

    (1975)
  • JW Gofman et al.

    Ischemic heart disease, atherosclerosis and longevity

    Circulation

    (1966)
  • WB Kannel et al.

    Serum cholesterol lipoproteins, and risk of coronary heart diseases. The Framingham Study

    Ann Intern Med

    (1971)
  • T Gordon et al.

    Introduction and general background in the Framingham Study. The Framingham Study

    (1968)
  • D Shurtleff

    Some characteristics related to the incidence of cardiovascular disease and death. Framingham Study: 18-year follow-up

  • DS Fredrickson et al.

    Fat transport and lipoproteins—an integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport and lipoproteins—an integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport and lipoproteins—an integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport and lipoproteins—an integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
    DS Fredrickson et al.

    Fat transport and lipoproteins—an integrated approach to mechanisms and disorders

    N Engl J Med

    (1967)
  • Cited by (4237)

    • Cardiovascular risk: From overweight to Framingham

      2024, Archives des Maladies du Coeur et des Vaisseaux - Pratique
    • Update of HDL in atherosclerotic cardiovascular disease

      2023, Clinica e Investigacion en Arteriosclerosis
    View all citing articles on Scopus
    1

    From the Framingham Heart Disease Epidemiology Study, National Heart, Lung and Blood Institute, Bethesda, Maryland.

    View full text