Table 1

Median (IQR) values of biomarkers in 1176 fasting men with no CVD at entry by status defined by type of first event occurring during follow-up

Biomarker	No event during follow-up		New MI/IHD event during follow-up			New stroke event during follow-up			New CHF event during follow-up
Biomarker	n	Median (IQR)	n	Median (IQR)	P	n	Median (IQR)	P	n	Median (IQR)	P
Cardiac and vascular
Troponin (pg/mL)	751	5.4 (4.3–6.8)	186	6.3 (5.1–7.6)	<0.001	125	5.4 (4.6–7.3)	0.37	51	6.9 (5.2–9.6)
BNP (pg/mL)	743	19.9 (12.8–30.2)	184	21.6 (13.1–35.4)	0.13	124	23.8 (15.9–41.2)	0.002	53	35.5 (20.5–65.0)	<0.001
Inflammatory
CRP (mg/L)	748	2.05 (1.07–4.13)	188	2.56 (1.49–4.54)	0.01	127	2.31 (1.25–4.05)	0.19	51	2.75 (1.57–4.69)	0.10
IL-6 (pg/mL)	750	2.04 (1.42–3.22)	188	2.07 (1.49–3.27)	0.33	127	2.31 (1.63–3.07)	0.11	51	2.21 (1.56–3.24)	0.29
IL-6 receptor (ng/mL)	751	37.8 (30.5–44.9)	188	38.0 (30.8–46.9)	0.55	126	37.7 (29.8–45.0)	0.61	51	38.0 (28.8–43.7)	0.62
Lipids
Cholesterol (mmol/L)	781	6.0 (5.3–6.8)	195	6.5 (6.0–7.2)	<0.001	137	6.0 (5.4–6.6)	0.77	54	6.2 (5.5–6.9)	0.50
Triglyceride (mmol/L)	781	1.5 (1.1–2.2)	195	1.7 (1.3–2.4)	<0.001	137	1.5 (1.1–2.2)	0.83	54	1.6 (1.0–2.0)	0.37
Lp-a (mg/dL)	743	7.5 (3.5–18.5)	188	11.4 (5.1–30.8)	0.001	127	7.3 (2.6–30.6)	0.97	51	6.6 (2.4–20.1)	0.42
Adhesion molecules
VCAM-1 (ng/mL)	750	1282 (1153–1437)	188	1272 (1106–1463)	0.68	127	1317 (1162–1454)	0.35	51	1322 (1216–1497)	0.08
E-selectin (ng/mL)	751	25.8 (19.0–33.4)	188	25.4 (19.0–34.8)	0.91	127	27.9 (21.3–37.0)	0.04	51	30.2 (20.6–38.6)	0.16
Liver function
Alkaline phosphatase (IU/L)	776	85 (70–102)	194	86 (71–103)	0.42	137	92 (74–111)	0.003	54	87 (70–105)	0.60
Aspartate transaminase (IU/L)	773	22 (18–27)	192	21 (18–25)	0.07	137	20 (17–25)	0.001	53	24 (19–29)	0.22
Alanine transaminase (IU/L)	777	22 (17–29)	193	23 (16–28)	0.86	137	21 (17–26)	0.40	54	23 (18–29)	0.45
Gamma-GT (IU/L)	781	27 (20–42)	195	30 (21–44)	0.13	137	28 (20–40)	0.97	54	28 (23–38)	0.41
Glutamate dehydrogenase (IU/L)	362	2.0 (1.2–3.3)	102	2.2 (1.2–3.7)	0.57	65	2.0 (1.0–3.3)	0.94	25	2.3 (1.0–3.4)	0.99
Acute phase
White cell count (×10⁹/L)	779	5.92 (5.07–7.07)	196	6.41 (5.30–7.43)	0.006	137	6.20 (5.13–7.70)	0.07	54	6.30 (4.86–7.26)	0.50
Viscosity (mPa·s)	776	167 (162–173)	195	170 (164–176)	<0.001	137	169 (163–176)	0.008	54	170 (164–180)	0.03
Fibrinogen (g/L)	771	390 (340–450)	195	410 (360–480)	<0.001	136	410 (370–470)	0.02	54	400 (340–470)	0.39
Ferritin (ng/mL)	750	112 (64–204)	187	113 (73–171)	0.94	126	1166 (67–184)	0.97	51	136 (70–216)	0.63
Leucocyte activation
GDF-15 (pg/mL)	751	684 (521–876)	188	717 (571–916)	0.10	127	708 (566–931)	0.07	51	742 (607–910)	0.10
PAPP-A (ng/mL)	749	7.12 (5.12–9.26)	188	7.27 (5.23–9.32)	0.75	127	7.65 (5.88–9.68)	0.05	51	7.80 (6.22–9.40)	0.08
Renal function
Cystatin-C (mg/L)	748	0.83 (0.75–0.92)	188	0.85 (0.77–0.92)	0.12	127	0.85 (0.78–0.93)	0.05	51	0.87 (0.77–0.96)	0.15
Creatinine (mg/dL)	775	97 (88–106)	194	97 (88–106))	0.49	137	97 (88–106))	0.40	53	97 (88–106)	0.53
Insulin resisitance
Glucose (mmol/L)	777	5.2 (4.9–5.6)	195	5.4 (5.0–5.9)	0.02	137	5.4 (5.0–6.0)	0.005	54	5.5 (5.0–5.8)	0.09
Retinol-binding protein (mg/L)	750	31.6 (26.0–37.9)	188	31.9 (26.1–37.9)	1.00	126	29.2 (24.8–34.9)	0.04	51	29.4 (24.6–36.0)	0.06
Fetuin-A (mg/L)	749	256 (218–306)	188	273 (224–321)	0.16	126	266 (226–308)	0.30	51	265 (236–298)	0.51
Others
Uric acid (mg/L)	780	33 (29–39)	195	33 (29–38)	0.89	137	33 (28–38)	0.43	54	35 (30–39)	0.79
Vitamin B6 (nmol/L)	750	40.9 (30.4–56.0)	184	40.3 (29.0–54.5)	0.41	122	37.2 (27.3–50.6)	0.05	54	37.8 (29.4–51.1)	0.42

P values are for comparisons with the no event group.
BNP, B-type natriuretic peptide; CHF, congestive heart failure; CRP, C reative protein; CVD, cardiovascular disease; GDF-15, growth differentiation factor-15; IHD, ischaemic heart disease; IL, interleukin; Lp-a, lipoprotein-a; MI, myocardial infarction; PAPP-A, pregnancy-associated plasma protein-A; VCAM-1, vascular cell adhesion molecule-1.