Biomarker | MI/IHD | Stroke | Congestive Heart failure |
Sub-hazard ratio (95% CI) | Sub-hazard ratio (95% CI) | Sub-hazard ratio (95% CI) | |
Troponin | 1.30 (1.07 to 1.59) | 0.83 (0.64 to 1.06) | 1.84 (1.21 to 2.80) |
BNP | 1.10 (0.91 to 1.33) | 1.33 (1.04 to 1.70) | 1.94 (1.26 to 2.97) |
CRP | 1.10 (0.90 to 1.35) | 1.01 (0.80 to 1.28) | 1.00 (0.71 to 1.41) |
IL-6 | 0.94 (0.78 to 1.14) | 1.14 (0.91 to 1.42) | 0.84 (0.57 to 1.22) |
IL-6 receptor | 1.02 (0.84 to 1.23) | 0.92 (0.72 to 1.16) | 1.04 (0.74 to 1.47) |
Cholesterol | 1.55 (1.27 to 1.88) | 0.89 (0.72 to 1.10) | 1.13 (0.78 to 1.63) |
Triglyceride | 1.08 (0.88 to 1.33) | 1.01 (0.81 to 1.25) | 0.77 (0.54 to 1.10) |
Lp-a | 1.35 (1.12 to 1.63) | 0.90 (0.71 to 1.13) | 0.69 (0.45 to 1.04) |
VCAM-1 | 0.90 (0.75 to 1.10) | 1.05 (0.84 to 1.32) | 1.28 (0.88 to 1.86) |
E-selectin | 0.88 (0.73 to 1.07) | 1.17 (0.93 to 1.47) | 1.16 (0.79 to 1.69) |
Alkaline phosphatase | 0.92 (0.76 to 1.11) | 1.22 (0.98 to 1.51) | 0.92 (0.65 to 1.33) |
Aspartate transaminase | 0.83 (0.69 to 1.00) | 0.77 (0.61 to 0.98) | 1.31 (0.91 to 1.84) |
Alanine transaminase | 0.96 (0.79 to 1.18) | 0.99 (0.79 to 1.25) | 1.00 (0.70 to 1.43) |
Gamma-GT | 0.89 (0.73 to 1.09) | 1.00 (0.79 to 1.26) | 0.98 (0.71 to 1.34) |
Glutamate dehydrogenase | 1.00 (0.78 to 1.32) | 1.07 (0.77 to 1.49) | 1.11 (0.66 to 1.85) |
White cell count | 1.20 (1.00 to 1.45) | 1.20 (0.93 to 1.53) | 1.13 (0.75 to 1.70) |
Viscosity | 1.12 (0.93 to 1.35) | 1.13 (0.90 to 1.41) | 1.21 (0.84 to 1.75) |
Fibrinogen | 1.16 (0.96 to 1.39) | 1.11 (0.89 to 1.37) | 0.95 (0.65 to 1.38) |
Ferritin | 0.94 (0.79 to 1.13) | 1.02 (0.81 to 1.28) | 1.33 (0.88 to 2.01) |
GDF-15 | 0.95 (0.77 to 1.17) | 0.94 (0.74 to 1.21) | 1.08 (0.71 to 1.66) |
PAPP-A | 1.02 (0.84 to 1.23) | 1.14 (0.91 to 1.44) | 1.41 (1.00 to 1.97) |
Cystatin | 1.01 (0.83 to 1.23) | 1.14 (0.90 to 1.45) | 1.01 (0.66 to 1.53) |
Creatinine | 0.85 (0.70 to 1.02) | 0.89 (0.71 to 1.12) | 1.21 (0.80 to 1.82) |
Glucose | 1.09 (0.88 to 1.34) | 1.12 (0.88 to 1.42) | 1.07 (0.76 to 1.49) |
RBP-4 | 0.93 (0.77 to 1.11) | 0.84 (0.66 to 1.07) | 0.82 (0.58 to 1.17) |
Fetuin-A | 1.03 (0.86 to 1.24) | 1.11 (0.88 to 1.41) | 1.31 (0.94 to 1.82) |
Uric acid | 0.94 (0.78 to 1.13) | 1.04 (0.81 to 1.33) | 1.19 (0.83 to 1.71) |
Vitamin B6 | 1.00 (0.82 to 1.21) | 0.96 (0.76 to 1.21) | 1.12 (0.79 to 1.57) |
Results in bold are significant (P<0.01).
Adjusted for covariates: age, smoking, diabetes, systolic blood pressure, total cholesterol, total triglycerides, body mass index and family history of premature CHD.
BNP, B-type natriuretic peptide; CHD, coronary heart disease; CRP, C reactive protein; CVD, cardiovascular disease; GDF-15, growth differentiation factor-15; IHD, ischaemic heart disease; IL, interleukin; Lp-a, lipoprotein-a; MI, myocardial infarction; PAPP-A, pregnancy- associated plasma protein-A; RBP-4, retinol binding protein-4; VCAM-1, vascular cell adhesion molecule-1.