Enriched gene ontology terms for significantly higher total and phosphorylated protein levels in the right ventricle of patients with tetralogy of Fallot compared with ventricular septal defect
| Ontology | Protein type | GO term | Description | P value | Proteins (n) | Protein symbol |
| Cellular component | Total | GO:0044449 | Contractile fibre part | 4E-05 | 11 | CFL2, CMYA5, CSRP3, FHOD3, FLNC, MYOM1, MYOZ2, NEBL, OBSCN, RYR2, SVIL |
| GO:0030018 | Z-disc | 9E-05 | 8 | CFL2, CSRP3, FHOD3, FLNC, MYOZ2, NEBL, OBSCN, RYR2 | ||
| Phosphorylated | GO:0042641 | Actomyosin | 6E-05 | 4 | CDC42BPB, MYO18A, NEBL, SORBS1 | |
| GO:0036477 | Somatodendritic compartment | 1E-04 | 2 | MAPT, STX4 | ||
| GO:0044449 | Contractile fibre part | 7E-04 | 5 | AHNAK, BAG3, JPH2, NEBL, OBSCN | ||
| GO:0030018 | Z-disc | 8E-04 | 4 | BAG3, JPH2, NEBL, OBSCN | ||
| Molecular function | Total | GO:0045294 | Alpha-catenin binding | 1E-05 | 3 | AJUBA, CDH2, PKP2 |
| GO:0003779 | Actin binding | 4E-05 | 14 | AJUBA, CFL2, CSRP3, FHOD3, FLII, FLNC, LIMCH1, MYOZ2, NEBL, SNTA1, SNTB2, SORBS1, SVIL, TWF2 | ||
| GO:0005516 | Calmodulin binding | 9E-04 | 7 | CAMK2D, OBSCN, PPP3CC, RYR2, SNTA1, SNTB2, STRN | ||
| Biological process | GO:0010881 | Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 3E-05 | 4 | CAMK2D, GSTM2, PLN, RYR2 | |
| GO:0031032 | Actomyosin structure organisation | 9E-05 | 7 | CFL2, CSRP3, FHOD3, LIMCH1, MYOZ2, OBSCN, SORBS1 | ||
| GO:0010882 | Regulation of cardiac muscle contraction by calcium ion signalling | 9E-05 | 4 | CAMK2D, GSTM2, PLN, RYR2 | ||
| GO:0014706 | Striated muscle tissue development | 1E-04 | 6 | CFL2, CSRP3, MYOM1, PLN, SEMA3C, SVIL, | ||
| GO:1903522 | Regulation of blood circulation | 1E-04 | 9 | ADCY6, CAMK2D, CSRP3, GSTM2, PKP2, PLN, RYR2, SNTA1, TMEM65 | ||
| GO:0060537 | Muscle tissue development | 1E-04 | 6 | CFL2, CSRP3, MYOM1, PLN, SEMA3C, SVIL | ||
| GO:0010880 | Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 2E-04 | 4 | CAMK2D, GSTM2, PLN, RYR2 | ||
| GO:0008016 | Regulation of heart contraction | 2E-04 | 8 | CAMK2D, CSRP3, GSTM2, PKP2, PLN, RYR2, SNTA1, TMEM65 | ||
| GO:0007010 | Cytoskeleton organisation | 3E-04 | 16 | AJUBA, CFL2, CSRP3, ERBB2IP, FHOD3, FLII, LIMCH1, MYOZ2, NTMT1, OBSCN, PKP2, PRKCDBP, SHANK1, SORBS1, SVIL, TUBA4A | ||
| GO:0055119 | Relaxation of cardiac muscle | 4E-04 | 3 | CAMK2D, GSTM2, PLN | ||
| GO:0086005 | Ventricular cardiac muscle cell action potential | 4E-04 | 3 | PKP2, RYR2, SNTA1 | ||
| GO:0055117 | Regulation of cardiac muscle contraction | 4E-04 | 5 | CAMK2D, GSTM2, PKP2, PLN, RYR2 | ||
| GO:0002026 | Regulation of the force of heart contraction | 4E-04 | 4 | CAMK2D, CSRP3, PLN, RYR2 | ||
| GO:1901077 | Regulation of relaxation of muscle | 6E-04 | 2 | CAMK2D, PLN | ||
| GO:1901897 | Regulation of relaxation of cardiac muscle | 6E-04 | 2 | CAMK2D, PLN | ||
| GO:0002027 | Regulation of heart rate | 8E-04 | 5 | CAMK2D, PKP2, PLN, RYR2, SNTA1 | ||
| GO:0006942 | Regulation of striated muscle contraction | 1E-03 | 5 | CAMK2D, GSTM2, PKP2, PLN, RYR2 | ||
| GO:0090075 | Relaxation of muscle | 1E-03 | 3 | CAMK2D, GSTM2, PLN | ||
| Phosphorylated | GO:0031032 | Actomyosin structure organisation | 1E-05 | 5 | CDC42BPB, MYLK3, MYO18A, OBSCN, SORBS1 | |
| GO:0050789 | Regulation of biological process | 3E-04 | 25 | AHNAK, BAG3, BVES, CDC42BPB, JPH2, KANK2, KPNA4, LRRFIP2, MAPT, MYLK3, MYO18A, NUCKS1, OBSCN, OSBP, PLCL1, PLN, PSIP1, RBM20, RSF1, SCN7A, SGTA, SORBS1, SPEG, STX4, ZBTB7A | ||
| GO:0050848 | Regulation of calcium-mediated signalling | 4E-04 | 3 | JPH2, MAPT, PLN | ||
| GO:1901019 | Regulation of calcium ion transmembrane transporter activity | 4E-04 | 3 | AHNAK, JPH2, PLN |