Table 3

Correlations between biomarkers and imaging characteristics among genotype-positive individuals

NT-proBNPhsTnISoluble ST2Galectin-3Periostin
Beta (SE)p ValueBeta (SE)p ValueBeta (SE)p ValueBeta (SE)p ValueBeta (SE)p Value
LA diameter0.67(0.12)<0.00010.64 (0.11)<0.00010.14 (0.12)0.220.22 (0.13)0.090.11 (0.12)0.35
LVEDD z-score−0.14 (0.06)0.018−0.01 (0.06)0.910.01 (0.05)0.790.03 (0.07)0.610.04 (0.06)0.58
LVESD z-score−0.12 (0.06)0.0330.02 (0.05)0.720.02 (0.05)0.680.04 (0.06)0.490.02 (0.05)0.67
LVWT z-score0.11 (0.01)<0.00010.06 (0.01)<0.0001−0.01 (0.01)0.590.01 (0.02)0.630.02 (0.01)0.15
LVEF, %0.01 (0.01)0.20−0.002 (0.01)0.84−0.002 (0.01)0.79−0.02 (0.01)0.090.001 (0.01)0.96
E/A ratio−0.19 (0.14)0.19−0.34 (0.15)0.03−0.10 (0.13)0.45−0.49 (0.14)0.0010.03 (0.16)0.84
Deceleration time0.0004 (0.002)0.810.004 (0.002)0.020.002 (0.001)0.060.002 (0.002)0.23−0.002 (0.002)0.21
Global e' z-score−0.21(0.02)<0.0001−0.16 (0.02)<0.00010.01 (0.03)0.65−0.05 (0.03)0.15−0.03 (0.03)0.21
Global s' z-score−0.20 (0.05)0.0002−0.13 (0.04)0.0030.08 (0.03)0.02−0.04 (0.05)0.42−0.07 (0.04)0.10
CMR LGE, %0.07 (0.01)<0.00010.02 (0.01)0.020.02 (0.01)0.030.01 (0.01)0.240.07 (0.01)<0.001
Exercise duration−0.13 (0.03)0.0001−0.04 (0.03)0.150.01 (0.03)0.66−0.03 (0.03)0.31−0.03 (0.03)0.40
Peak MET−0.12 (0.02)<0.0001−0.05 (0.03)0.070.02 (0.02)0.46−0.05 (0.03)0.12−0.03 (0.03)0.19
  • Beta coefficient represents the change in imaging characteristic per 1 SD increase in log-transformed biomarker, after adjustment for age, sex and familial correlation.

  • CMR, cardiac MRI; hsTnI, high-sensitivity troponin I; LA, left atrial; LGE, late gadolinium enhancement; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systolic dimension; LVWT, left ventricular wall thickness; MET, metabolic equivalent; NT-proBNP, N-terminal pro-B-type natriuretic peptide.