Categorical clinical features in the national cohort of paediatric patients with HCM: SD/CA individuals compared with survivors
| Characteristics | SD/CA n=39 (32 for ECG) (% of total) | Survivors (surv) n=100 (% of total) | p Value Fisher’s exact (SD/CA vs surv) |
| Proportion male | 66.7 | 62.3 | n.s. |
| Syndrome-related HCM | 15.6 | 18.9 | n.s. |
| Familial HCM | 53.3 | 62.5 | n.s. |
| Family history of sudden death | 27.6 | 30.0 | n.s. |
| LVOTO at rest at diagnosis | 67.9 | 36.0 | p=0.0044 |
| Cardiac syncope | 10.0 | 15.1 | n.s. |
| nsVT on Holter | 73.7 | 10.8 | p<0.0001 |
| QRS axis deviation on ECG | 66.7 | 41.0 | p=0.015 |
| Pathological T wave inversion | 61.3 | 40.4 | p=0.06 (n.s.) |
| Precordial T wave inversion | 48.4 | 27.7 | p=0.028 |
| ST depression at rest | 43.3 | 8.4 | p<0.0001 |
| Dominant S in V4 | 65.6 | 32.3 | p=0.0016 |
| Pre-excitation ECG | 0 | 1.1 | n.s. |
| Beta-blocker therapy | 53.1 | 81.8 | p=0.0021 |
| Calcium-blocker therapy | 12.9 | 7.0 | n.s. |
| Beta-blocker+disopyramide | 12.9 | 30.0 | p=0.06 (n.s.) |
| Amiodarone therapy | 3.2 | 5.0 | n.s. |
| No medical therapy | 37.5 | 12.0 | p=0.0028 |
| Myectomy | 18.8 | 9.1 | n.s. |
| Pacing therapy (for LVOT obstruction) | 6.3 | 7.1 | n.s. |
HCM, hypertrophic cardiomyopathy; LVOT, left ventricular outflow tract; LVOTO, left ventricular outflow tract obstruction; n.s., not statistically significant; nsVT, non-sustained ventricular tachycardia; SD/CA, sudden death/cardiac arrest.