Effect of SRT2104 on serum lipid concentrations
| Placebo (n=14) | SRT2104 (n=15) | p Value | |
| Total cholesterol (mean (SD)), mmol/L | 0.158 | ||
| Baseline | 4.09 (0.743) | 4.24 (0.714) | |
| Day 28/56 | 3.91 (0.843) | 3.65 (0.710) | |
| Change from baseline | −0.18 (0.410) | −0.59 (0.766) | |
| Mean difference (95% CI) | −0.36 (−0.87 to 0.16) | ||
| HDL cholesterol, (mean (SD)), mmol/L | |||
| Baseline | 1.07 (0.212) | 1.08 (0.207) | 0.542 |
| Day 28/56 | 1.09 (0.210) | 1.07 (0.249) | |
| Change from baseline | 0.03 (0.080) | 0.00 (0.167) | |
| Mean difference (95% CI) | −0.03 (-0.13 to 0.07) | ||
| LDL cholesterol,(mean (SD)), mmol/L | |||
| Baseline | 2.21 (0.585) | 2.29 (0.552) | 0.259 |
| Day 28/56 | 2.05 (0.692) | 1.90 (0.656) | |
| Change from baseline | −0.15 (0.467) | −0.39 (0.656) | |
| Mean difference (95% CI) | −0.23 (-0.65 to 0.19) | ||
| Triglycerides,(mean (SD)), mmol/L | |||
| Baseline | 1.81 (0.800) | 1.93 (0.767) | 0.150 |
| Day 28/56 | 1.67 (0.497) | 1.46 (0.445) | |
| Change from baseline | −0.14 (0.568) | −0.46 (0.638) | |
| Mean difference (95% CI) | −0.22 (-0.53 to 0.09) | ||