Table 6

Multivariate analysis of right ventricular structure and function stratified by obstructive lung disease status

Variable	Age of initiation		Cigarettes per day		Pack-years
Variable	Estimate	p	Estimate	p	Estimate	p
No airflow obstruction
RVAd, cm²	0.011	0.54	0.032	0.0191	0.001	0.87
RVFAC	−0.002	0.0008	0.0002	0.50	−0.0004	<0.0001
TAPSE, cm	−0.001	0.60	0.005	0.0089	−0.0003	0.46
RV peak S velocity, cm/s	−0.032	0.0004	0.029	<0.0001	−4.3E-05	0.98
RVOT VTI, cm	0.070	<0.0001	−0.007	0.0137	−0.011	0.0012
Right ventricular stroke volume, mL	0.716	<0.0001	−0.193	0.0152	−0.086	0.0001
TR max velocity, cm/s	0.003	0.0021	0.005	0.0049	−0.0003	0.62
TR max PG, mm Hg	0.020	0.19	0.065	0.0065	−0.004	0.66
Airflow obstruction
RVAd, cm²	0.069	0.11	−0.063	<0.0001	0.010	0.07
RVFAC	0.006	0.0003	−0.001	0.0019	−0.001	<0.0001
TAPSE, cm	0.019	<0.0001	−0.010	<0.0001	−0.003	<0.0001
RV peak S velocity, cm/s	0.023	0.29	−0.004	0.5073	−0.009	<0.0001
RVOT VTI, cm	0.082	0.024	−0.070	<0.0001	−0.035	<0.0001
Right ventricular stroke volume, mL	1.269	0.001	−0.456	<0.0001	−0.144	<0.0001
TR max velocity, cm/s	0.023	0.0005	0.006	<0.0001	0.002	<0.0001
TR max PG, mm Hg	0.390	0.001	0.091	<0.0001	0.029	0.0003

Bold denotes statistically significant associations (p≤0.01).
PG, peak gradient; RVAd, right ventricular area at diastole; RVFAC, right ventricular fractional area change; RVOT, right ventricular outflow tract; TAPSE, tricuspid annular plane systolic excursion; TR, tricuspid regurgitation; VTI, velocity time integral.