Table 2

Laboratory and echocardiographic data

	First tertile (n=353)	Second tertile (n=353)	Third tertile (n=352)	p Value
Laboratory data
Log BNP	2.2±0.6	2.5±0.5	2.6±0.5**^††	<0.001
Total protein (g/L)	7.1±0.8	7.0±0.7	6.8±0.8**^††	<0.001
Albumin (g/L)	3.8±0.6	3.7±0.6	3.5±0.6**^††	<0.001
Total bilirubin (mg/dL)	0.9±0.5	0.9±0.5	1.1±0.7	0.146
Direct bilirubin (mg/dL)	0.1±0.1	0.1±0.1	0.2±0.2	0.086
Alkaline phosphatase (U/L)	246.4±114.3	257.9±134.2	280.8±114.4**	0.008
Gamma-glutamyl transferase (U/L)	55.9±64.1	60.0±96.3	76.6±95.5**	0.009
Cholinesterase (U/L)	294.1±88.2	266.2±77.1	215.0±70.0**^††	<0.001
Estimated GFR (mL/min/1.73 cm²)	62.6±25.2	56.4±22.3**	48.1±21.8**^††	<0.001
Sodium (mEq/L)	138.9±3.3	139.2±3.6	138.4±4.4^†	0.018
Type IV collagen 7S (ng/mL)	4.5±1.7	4.8±1.7*	5.9±2.5**^††	<0.001
PIIIP (U/mL)	0.6±0.3	0.7±0.4*	0.8±0.3**^†	<0.001
Log hyaluronic acid	1.6±0.3	1.9±0.4**	2.1±0.4**^††	<0.001
Echocardiography
LVEF (%)	49.0±17.0	50.0±15.9	50.2±14.9	0.640
Left atrial volume (mL)	74.9±47.9	82.8±56.6	92.5±72.0**	0.004
Mitral valve E/e’	13.8±7.0	15.3±9.8	16.6±9.1**	0.004
Inferior vena cava diameter (mm)	14.4±4.6	14.5±4.4	16.2±5.4**^††	<0.001
SPAP (mm Hg)	30.3±18.5	30.2±15.2	31.0±14.9	0.854
Right atrial end-systolic area (cm²)	17.6±10.4	17.4±8.5	20.9±11.1**^††	0.003
RV-FAC (%)	42.1±15.8	41.6±13.3	41.7±14.3	0.941

Data are presented as median (IQR).
*p<0.05 and **p<0.01 versus
*p<0.05 and **p<0.01 versus first tertile. †p<0.05 and ††p<0.01 versus second tertile.
BNP, B-type natriuretic peptide; GFR, glomerular filtration rate; LVEF, left ventricular ejection fraction; Mitral valve E/e’, ratio of the peak transmitral velocity during early diastole to the peak mitral valve annular velocity during early diastole; PIIIP, procollagen type III peptide; RV-FAC, right ventricular fractional area change; SPAP, systolic pulmonary artery pressure.