Adverse events in operated and unoperated patients with severe aortic stenosis in the year following inclusion
| Event | Surgical AVR, n=351 | Unoperated, n=91 | |||||
| n (%) |
Time at risk (years) | Rate/time * | n (%) |
Time at risk (years) | Rate/time * | p Value † | |
| All-cause mortality | 16 (4.6) | 340 | 4.7 | 17 (18.7) | 83 | 20.4 | <0.0001 |
| MACE | 43 (12.3) | 318 | 13.5 | 21 (23.1) | 80 | 26.3 | 0.009 |
| TIA | 8 (2.3) | 335 | 2.4 | None | 83 | None | 0.084 |
| Stroke | 21 (6.0) | 325 | 6.5 | 3 (3.3) | 83 | 3.6 | 0.179 |
| TIA or stroke | 28 (8.0) | 322 | 8.7 | 3 (3.3) | 83 | 3.6 | 0.065 |
| New pacemaker | 21 (6.0) | 324 | 6.5 | 6 (7.7) | 79 | 7.6 | 0.359 |
| Myocardial infarction | 4 (1.1) | 338 | 1.2 | 10 (11.0) | 83 | 12.1 | <0.0001 |
| Endocarditis | 8 (2.3) | 335 | 2.4 | 1 (1.1) | 84 | 1.2 | 0.286 |
| Antibiotic-requiring infection | 116 (33.0) | 246 | 47.2 | 15 (16.5) | 80 | 18.9 | 0.0001 |
| Cardiac hospitalisation‡ | 32 (9.1) | 322 | 9.9 | 27 (29.7) | 77 | 35.1 | <0.0001 |
| All-cause hospitalisation‡ | 148 (42.2) | 237 | 62.4 | 41 (45.1) | 68 | 60.3 | 0.411 |
| Any-cause 30-day rehospitalisation§ | 90 (25.6) | 292§ | 31.8§ | 2 (2.2) | 85§ | 2.4§ | <0.0001 |
*Rate per 100 patient-years.
†p Values for comparison of incidence rates in operated and unoperated patients.
‡Hospitalisation defined as at least an overnight stay.
§Thirty days counting from discharge after postoperative recovery in local hospital, or from inclusion date for unoperated patients. Time at risk per 30 days and rate per 100 patient months.
AVR, aortic valve replacement; MACE, major adverse cardiovascular event (see definition in the Methods section); TIA, transient ischaemic attack.