Sleep apnoea indices and plasma levels of endothelin-1
| n=1255 | β (95% CI) | p Value |
|---|---|---|
| Respiratory event index 5–14 | ||
| Crude model | 0.17 (0.10 to 0.24) | <0.0001 |
| Age, sex and BMI adjusted model | 0.14 (0.07 to 0.21) | <0.0001 |
| Multivariable model* | 0.13 (0.06 to 0.20) | 0.0002 |
| Oxygen-desaturation index ≥5 | ||
| Crude model | 0.14 (0.08 to 0.20) | <0.0001 |
| Age, sex and BMI adjusted model | 0.11 (0.04 to 0.17) | 0.0012 |
| Multivariable model* | 0.10 (0.03 to 0.16) | 0.003 |
| Mean night-time SpO2 (%) | ||
| Crude model | −0.034 (−0.046 to −0.021) | <0.0001 |
| Age, sex and BMI adjusted model | −0.022 (−0.036 to −0.007) | 0.003 |
| Multivariable model* | −0.018 (−0.033 to −0.003) | 0.02 |
| Per cent of time with SpO2<90% | ||
| Crude model | 0.021 (0.011 to 0.032) | <0.0001 |
| Age, sex and BMI adjusted model | 0.015 (0.004 to 0.025) | 0.008 |
| Multivariable model* | 0.012 (0.002 to 0.023) | 0.02 |
Multivariable linear regression models. Endothelin-1 was log-transformed. Per cent of sleeping time with SpO2<90% was log-transformed.
*Adjustment for age, sex, BMI, high-sensitivity C reactive protein, glomerular filtration rate, HbA1c, systolic and diastolic ambulatory blood pressure, low-density lipoprotein, high-density lipoprotein, triglycerides and smoking status.
β, β coefficient; BMI, body mass index; HbA1c, glycated haemoglobin; SpO2, blood oxygen saturation.