Table 4

Associations between echocardiographic measures at baseline and changes at 6 months with CTRCD at 12 months (n=103)

Echocardiographic measureAdjusted OR* (95% CI)p Value
Strain
 Longitudinal strain, %
  Baseline†1.09 (0.856 to 1.38)0.493
  Change‡1.18 (0.949 to 1.47)0.137
 Circumferential strain, %
  Baseline†0.883 (0.743 to 1.05)0.159
  Change‡0.862 (0.731 to 1.02)0.079
 Radial strain, %
  Baseline†1.00 (0.967 to 1.03)0.978
  Change‡1.00 (0.978 to 1.02)0.973
Strain rate
 Longitudinal strain rate, 0.1/s
  Baseline§1.17 (0.843 to 1.62)0.350
  Change¶1.51 (1.08 to 2.12)0.016
 Circumferential strain rate, 0.1/s
  Baseline§1.01 (0.844 to 1.22)0.882
  Change¶0.985 (0.859 to 1.13)0.834
 Radial strain rate, 0.1/s
  Baseline§0.985 (0.911 to 1.07)0.711
  Change¶0.993 (0.940 to 1.05)0.811
ESPVR and VA coupling
 Eessb, 0.1 mm Hg/mL
  Baseline**0.958 (0.848 to 1.08)0.490
  Change††0.997 (0.907 to 1.10)0.954
 V100, 10 mL
  Baseline‡‡0.661 (0.393 to 1.11)0.120
  Change§§2.13 (1.33 to 3.43)0.002
 Ea, 0.1 mm Hg/mL
  Baseline**1.06 (0.916 to 1.23)0.424
  Change††1.19 (1.04 to 1.36)0.010
 Ea/Eessb, 0.1 unit
  Baseline¶¶1.12 (0.881 to 1.42)0.357
  Change***1.12 (0.965 to 1.31)0.132

  • *Adjusted for age and sex.

  • †OR of CTRCD for every 1% difference at baseline.

  • ‡OR of CTRCD for every 1% increase from baseline to 6 months.

  • §OR of CTRCD for every 0.1/s difference at baseline.

  • ¶OR of CTRCD for every 0.1/s increase from baseline to 6 months.

  • **OR of CTRCD for every 0.1 mm Hg/mL difference at baseline.

  • ††OR of CTRCD for every 0.1 mm Hg/mL increase from baseline to 6 months.

  • ‡‡OR of CTRCD for every 10 mL difference at baseline.

  • §§OR of CTRCD for every 10 mL increase from baseline to 6 months.

  • ¶¶OR of CTRCD for every 0.1 unit difference at baseline.

  • ***OR of CTRCD for every 0.1 unit increase from baseline to 6 months.

  • CTRCD, Cancer Therapeutics-Related Cardiac Dysfunction; ESPVR, end-systolic pressure–volume relationship.