Table 3

Associations of baseline values and changes in measures of mechanics with CTRCD at the same follow-up visit (n=165)

Echocardiographic measureAdjusted OR* (95% CI)p Value
Strain
 Longitudinal strain, %
  Baseline†1.01 (0.995 to 1.03)0.182
  Change‡1.02 (1.01 to 1.03)0.004
 Circumferential strain, %
  Baseline†1.00 (0.993 to 1.01)0.526
  Change‡1.01 (1.00 to 1.02)0.009
 Radial strain, %
  Baseline†0.999 (0.996 to 1.00)0.413
  Change‡0.999 (0.998 to 1.00)0.241
Strain rate
 Longitudinal strain rate, 0.1/s
  Baseline§1.01 (0.994 to 1.03)0.201
  Change¶1.03 (1.01 to 1.04)0.003
 Circumferential strain rate, 0.1/s
  Baseline§1.01 (0.999 to 1.02)0.089
  Change¶1.01 (1.00 to 1.02)0.018
 Radial strain rate, 0.1/s
  Baseline§0.998 (0.994 to 1.00)0.422
  Change¶0.999 (0.996 to 1.00)0.420
ESPVR and VA coupling
 Eessb, 0.1 mm Hg/mL
  Baseline**1.01 (0.995 to 1.02)0.272
  Change††1.01 (0.999 to 1.02)0.068
 V100, 10 mL
  Baseline‡‡0.993 (0.957 1.03)0.703
  Change§§1.07 (1.04 to 1.10)<0.001
 Ea, 0.1 mm Hg/mL
  Baseline**1.01 (0.996 to 1.02)0.192
  Change††1.03 (1.02 to 1.04)<0.001
 Ea/Eessb, 0.1 unit
  Baseline¶¶0.998 (0.976 to 1.02)0.847
  Change***1.02 (1.00 to 1.04)0.034
  • *Adjusted for age and sex; baseline values and changes in measures are included in each model and their respective associations with CTCRD at follow-up visits are reported in the table.

  • †OR of CTRCD for every 1% difference at baseline.

  • ‡OR of CTRCD for every 1% increase from baseline.

  • §OR of CTRCD for every 0.1/s difference at baseline.

  • ¶OR of CTRCD for every 0.1/s increase from baseline.

  • **OR of CTRCD for every 0.1 mm Hg/mL difference at baseline.

  • ††OR of CTRCD for every 0.1 mm Hg/mL increase from baseline.

  • ‡‡OR of CTRCD for every 10 mL difference at baseline.

  • §§OR of CTRCD for every 10 mL increase from baseline.

  • ¶¶OR of CTRCD for every 0.1 unit difference at baseline.

  • ***OR of CTRCD for every 0.1 unit increase from baseline.

  • CTRCD, Cancer Therapeutics-Related Cardiac Dysfunction; ESPVR, end-systolic pressure–volume relationship.