The ECG characteristics of the LMNA mutation carriers, DCM controls and healthy controls
| LMNA mutation carriers, N=27% | DCM controls, N=78% | p Value LMNA vs DCM | Healthy controls, N=20% | p Value LMNA vs healthy control | |
|---|---|---|---|---|---|
| Rhythm | |||||
| Sinus rhythm | 70.4 | 75.6 | NS | 100 | NS |
| AF | 11.1 | 16.7 | 0 | ||
| Other* | 18.5 | 7.7 | 0 | ||
| First AV block | 37.0 (55.6)† | 15.4 (20.7) | 0.034 | 0 | 0.006 |
| Current or previous AV block | 59.3 | 24.4 | 0.002 | 0 | <0.001 |
| PTF | 22.2 (30.0) | 30.8 (40.0) | NS | 10.0 | NS |
| Flat P wave | 33.3 (45.0) | 6.4 (8.3) | 0.002 | 0 | 0.012 |
| Broad P wave | 7.4 (10.0) | 5.1 (6.7) | NS | 0 | NS |
| LVH | 7.4 (11.8) | 20.5 (34.0) | NS | 0 | NS |
| ST depression | 18.5 (29.4) | 32.1 (53.2) | NS | 5.0 | NS |
| T inversion | 7.4 (11.8) | 32.1 (53.2) | 0.012 | 5.0 | NS |
| QRS fragmentation | 37.0 | 33.3 | NS | 5.0 | 0.028 |
| Septal fragmentation | 22.2 | 6.4 | NS | 0 | 0.062 |
| Septal remodelling | 81.5 | 20.5 | <0.001 | 0 | <0.001 |
| Septal remodelling, flat P wave, or current or previous AV block | 96.3 | 41.0 | <0.001 | 0 | <0.001 |
| LBBB | 7.4 | 20.5 | NS | 0 | NS |
| RBBB | 0 | 2.6 | NS | 0 | NS |
| NSIVCD | 3.7 | 7.7 | NS | 0 | NS |
*Physiological pacemaker or third AV block.
†The prevalence in brackets of only those applicable.
AF, atrial fibrillation; AV block, atrioventricular block; DCM, dilated cardiomyopathy; LBBB, left bundle branch block; LVH, left ventricular hypertrophy; NS, not significant; NSIVCD, non-specific intraventricular conduction defect; PTF, P terminal force; RBBB, right bundle branch block.