Table 1

PICOS table

PICOS
Patient population

  • ▸ Patients with bicuspid aortic valve disease above 1 month of age

Interventions

  • ▸ Surgical valve repair

Comparators

  • ▸ Any comparator

OutcomesComplications before discharge:

  • ▸ Reoperation during index admission

  • ▸ Neurologic event

Mortality:

  • ▸ 30-day survival

  • ▸ Survival at 1, 5 and 10 years follow-up

  • ▸ Valve-related late mortality at follow-up

Complications at follow-up:

  • ▸ Operated valve endocarditis

  • ▸ Thrombosis, embolism and bleeding

Reinterventions at follow-up:

  • ▸ Reinterventions on operated valve at follow-up

  • ▸ Freedom from reintervention at 1, 5 and 10 years follow-up

Study designs

  • ▸ Any study design