Studies investigating MI size quantification techniques by CMR
| Study | No. | Techniques compared | Software | Result |
|---|---|---|---|---|
| Zhang et al 201615 | 114 AMI patients with matching follow-up scan at 6 months at 3 T | Manual, FWHM (20–50%), 1–9-SDs | Mass | FWHM 30% and 3-SD was closest to manual for total infarct size and FWHM45% and 6-SD was closest to manual for core infarct size |
| Dash et al 201537 (conference abstract) | 19 AMI porcine models | FWHM 5-SD 6-SD | CVI42 | 6-SD was more accurate to quantify MI size. FWHM and 5-SD overestimated MI size when compared with histology |
| McAlindon et al 20157 | 40 AMI at 1.5 T | Manual contouring 2,3,5-SDs Otsu FWHM | CVI42 | Manual contouring and FWHM provided the lowest inter, intraobserver and interscan variability for MI size |
| Khan et al 201512 | 10 AMI 1.5 T and 10AMI 3 T | 5–8-SDs FWHM Otsu | CVI42 | FWHM is accurate and reproducible 5-SD and Otsu overestimate MI size at 1.5 and 3 T. FWHM correlated strongest with LV ejection fraction |
| Vermes et al 201310 | 28 AMI 30 myocarditis | Visual 2,3,5-SDs Otsu FWHM | CVI42 | Otsu and 5-SD did not differ FWHM underestimated AMI LGE by 15% Otsu and FWHM showed best intraobserver and interobserver reproducibility |
| Flett et al 201111 | 20 AMI 20 CMI 20 HCM | Manual contouring 2–6-SDs FWHM | ImageJ (purpose-written macro) | AMI: No difference between Manual contouring and 6-SD CMI: No difference between Manual contouring, 6-SD and 5-SD FWHM similar to Manual contouring and more reproducible |
| Beek et al 20099 | 38 CMI with hibernating myocardium (CMR 1 month before and 6 months after revascularisation) | 2–8-SDs FWHM | Mass | 6-SD showed the highest accuracy to predict segmental functional recovery following revascularisation |
| Heiberg et al 200840 | 20 AMI 20 CMI 8 AMI porcine models | Weighted automated method vs 2–8-SDs | Segment | The weighted approach provides automatic quantification of myocardial infarction with higher accuracy and lower variability than a dichotomous algorithm |
| Hsu et al 200641/Hsu et al 200642 | 11 AMI canine models 11 AMI and 9 CMI | Manual contouring 2-SD FWHM FACT | Interactive display language/Microsoft visual C++ | The automated feature analysis and combined thresholding (FACT) accurately measured MI size in vivo and ex-vivo—more accurate than Manual contouring and SD Manual contouring and SD overestimated infarct size compared with FACT |
| Bondarenko et al 20058 | 15 CMI | 2–6-SDs | No difference between visual analysis and 5-SD | |
| Amado et al 200416 | 13 AMI canine models | Manual contouring 1–6-SDs FWHM | Cine tool | FWHM correlated best with postmortem data |
AMI, acute myocardial infarction; CMI, chronic myocardial infarction; CMR, cardiovascular magnetic resonance; FWHM, full width half maximum; MI, myocardial infarct.