Characteristics of patients with low eosinophil or low lymphocyte counts
| Patient group | All patients | Low eosinophils (<0.05×109/L) | Low lymphocytes (<1.45×109/L) |
|---|---|---|---|
| N patients | 775 231 | 44 112 | 133 220 |
| Women, n (%) | 461 956 (59.6%) | 29 990 (68.0%) | 80 119 (60.1%) |
| Age, median (IQR) | 52.4 (41.4–64.6) | 52 (39.8–66.8) | 55.8 (43.4–70.4) |
| Most deprived quintile, n (%) | 132 971 (17.2%) | 6931 (15.8%) | 18 982 (14.3%) |
| Ethnicity, n (%) | |||
| White | 445 034 (92.8%) | 25 511 (91.7%) | 80 558 (95.3%) |
| South Asian | 13 450 (2.8%) | 552 (2.0%) | 1134 (1.3%) |
| Black | 9974 (2.1%) | 1051 (3.8%) | 1214 (1.4%) |
| Other | 11 320 (2.4%) | 714 (2.6%) | 1598 (1.9%) |
| Missing | 295 453 (38.1%) | 16 284 (36.9%) | 48 716 (36.6%) |
| Smoking status, n (%) | |||
| Never | 386 702 (52.6%) | 25 034 (61.0%) | 76 478 (61.6%) |
| Ex | 177 199 (24.1%) | 8840 (21.5%) | 30 682 (24.7%) |
| Current | 171 021 (23.3%) | 7158 (17.4%) | 16 925 (13.6%) |
| Missing | 40 309 (5.2%) | 3080 (7.0%) | 9135 (6.9%) |
| Most recent value within 1 year prior to index date, median (IQR) | |||
| Systolic blood pressure | 136 (121–150) | 133 (120–148) | 136 (120–150) |
| Body mass index | 27.0 (23.8–31.1) | 25.0 (22.0–28.5) | 25.5 (22.5–29.0) |
| Total cholesterol | 5.5 (4.8–6.2) | 5.4 (4.6–6.1) | 5.3 (4.6–6.1) |
| HDL cholesterol | 1.4 (1.1–1.7) | 1.5 (1.2–1.8) | 1.5 (1.2–1.8) |
| eGFR | 81.9 (68.8–95.1) | 81.4 (67.6–95.4) | 78.9 (65.1–92.1) |
| Diagnoses on or before index date, n (%) | |||
| Atrial fibrillation | 7722 (1.0%) | 555 (1.3%) | 2358 (1.8%) |
| Cancer | 47 521 (6.1%) | 3895 (8.8%) | 13 109 (9.8%) |
| Diabetes | 37 127 (4.8%) | 1502 (3.4%) | 5807 (4.4%) |
| Asthma or atopy | 212 900 (27.5%) | 9783 (22.2%) | 36 750 (27.6%) |
| COPD | 15 021 (1.9%) | 863 (2.0%) | 3250 (2.4%) |
| Connective tissue disease | 21 859 (2.8%) | 1680 (3.8%) | 5629 (4.2%) |
| Inflammatory bowel disease | 8646 (1.1%) | 704 (1.6%) | 2337 (1.8%) |
COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein.