Table 2

Baseline characteristics, conditions at admission, management and outcomes according to P2Y12 use during hospitalisation in the FAST-MI registry

VariableC
N=2842 (69.3%)
P
N=391 (9.5%)
Switch C to P
N=678 (16.5%)
Switch P to C
N=190 (4.6%)
Male gender1913 (67.3%)348 (89.0%)573 (84.5%)158 (83.2%)
Age, years68±1456±1156±1156±11
STEMI1303 (45.8%)295 (75.4%)472 (69.6%)143 (75.3%)
Hypertension1699 (59.8%)144 (36.8%)286 (42.2%)57 (30.0%)
Hypercholesterolaemia1250 (44.0%)154 (39.4%)295 (43.5%)80 (42.1%)
Current smoking780 (27.4%)201 (51.4%)364 (53.7%)106 (55.8%)
Diabetes628 (22.1%)46 (11.8%)107 (15.8%)35 (18.4%)
Body weight, kg75±1580±1482±1481±18
Prior MI489 (17.2%)30 (7.7%)97 (14.3%)10 (5.3%)
Prior PCI457 (16.1%)37 (9.5%)108 (15.9%)13 (6.8%)
Prior CABG189 (6.7%)20 (5.1%)28 (4.1%)9 (4.7%)
History of HF156 (5.5%)2 (0.5%)11 (1.6%)1 (0.5%)
History of stroke131 (4.6%)3 (0.8%)6 (0.9%)0 (0.0%)
PAD269 (9.5%)15 (3.8%)31 (4.6%)5 (2.6%)
CKD145 (5.1%)4 (1.0%)11 (1.6%)1 (0.5%)
COPD195 (6.9%)22 (5.6%)37 (5.5%)12 (6.3%)
Admission Killip>2158 (5.8%)7 (1.9%)14 (2.1%)2 (1.1%)
Admission SBP, mm Hg145±29142±27145±26144±28
Admission HR, bpm80±2177±2077±1978±17
Early GRACE score147±37127±26125±29126±30
Creatinine, mmol/L101±10790±5787±2583±24
GFR, mL/min70±3789±2891±3096±40
Admission to centre with on-site cathlab1933 (68%)345 (88.2%)500 (73.7%)121 (63.7%)
Primary PCI804 (58.5%)253 (84.9%)328 (69.5%)110 (75.9%)
Coronary angioplasty2060 (72.4%)390 (93.0%)645 (95.1%)176 (92.6%)
Recurrent MI26 (0.9%)3 (0.8%)14 (2.1%)1 (0.5%)
Stent thrombosis8 (0.3%)3 (0.8%)9 (1.3%)1 (0.5%)
Major bleeding14 (0.5%)3 (0.8%)0 (0.0%)1 (0.5%)
Fatal bleeding1 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)
Hb drop of 3–5 g/dL226 (8.0%)20 (5.1%)49 (7.2%)17 (8.9%)
Hb drop≥5 g/dL60 (2.1%)10 (2.6%)6 (0.9%)4 (2.1%)
BARC bleed type 3A46 (1.6%)4 (1.0%)10 (1.5%)5 (2.6%)
BARC bleed type 3B70 (2.5%)10 (2.6%)6 (0.9%)4 (2.1%)
BARC bleed type 3C2 (0.1%)0 (0.0%)0 (0.0%)0 (0.0%)
Transfusion118 (4.2%)4 (1.0%)3 (0.4%)3 (1.6%)
In-hospital death98 (3.4%)2 (0.5%)2 (0.3%)1 (0.5%)
Combined end point*80 (3.9%)2 (0.8%)5 (1.0%)1 (0.8%)
One-year all-cause mortality290 (10.2%)5 (1.3%)12 (1.8%)2 (1.1%)
  • *Combined end point=death, stent thrombosis, stroke and/or BARC type ≥3 bleeding.

  • BARC, Bleeding Academic Research Consortium; C, clopidogrel; CABG, coronary artery bypass graft; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; FAST-MI, French Registry on Acute ST-elevation and non ST-elevation Myocardial Infarction; GFR, glomerular filtration rate estimated by the Cockroft-Gault formula; cathlab, catheterisation laboratory; GRACE, Global Registry of Acute Coronary Events; Hb, haemoglobin; HF, heart failure; HR, heart rate; kg, kilograms; MI, myocardial infarction; P, prasugrel; PAD, peripheral arterial disease; PCI, percutaneous coronary intervention; SBP, systolic blood pressure; STEMI, ST segment elevation myocardial infarction.