Changes in biochemical measures of renal function in otherwise healthy cigarette smokers and participants with type 2 diabetes mellitus administered placebo and SRT2104
| Otherwise healthy cigarette smokers (n=24) | Participants with type 2 diabetes (n=15) | |||||||
|---|---|---|---|---|---|---|---|---|
| Treatment period 1: placebo (n=13) | Treatment period 1: SRT2104 (n=11) | Treatment period 1: placebo (n=8) | Treatment period 1: SRT2104 (n=7) | |||||
| Day 1 | Day 28 | Day 1 | Day 28 | Day 1 | Day 28 | Day 1 | Day 28 | |
| Serum urea (mg/dL) | 17±3 | 14±3 | 11±3 | 14±3 | 17±3 | 17±3 | 17±6 | 14±3 |
| Serum creatinine (mg/dL) | 0.8±0.1 | 0.8±0.1 | 0.7±0.1 | 0.8±0.1 | 0.8±0.1 | 0.8±0.1 | 0.9±0.1 | 0.9±0.1 |
| Electrolytes | ||||||||
| Sodium (mmol/L) | 140±2 | 140±2 | 140±2 | 140±1 | 139±1 | 139±3 | 138±2 | 139±3 |
| Potassium (mmol/L) | 4.0±0.4 | 4.0±0.4 | 4.0±0.4 | 4.0±0.2 | 4.0±0.3 | 4.0±0.3 | 4.0±0.2 | 4.0±0.4 |
| Chloride (mmol/L) | 109±3 | 107±3 | 108±3 | 107±2 | 104±4 | 104±3 | 103±2 | 104±2 |
Values expressed as mean±SD.