Characteristics of asymptomatic versus symptomatic patients (mean±SD unless otherwise stated)
| Controls | Aortic stenosis | Mitral stenosis | Aortic regurgitation | Mitral regurgitation | ||
|---|---|---|---|---|---|---|
| Number of subjects | NYHA 1 | 39 | 17 | 16 | 32 | 16 |
| NYHA 2 | 17 | 14 | 7 | 17 | ||
| Total | 39 | 34 | 30 | 39 | 33 | |
| BNP (pg/mL) | NYHA 1 | 26.8±13.0 | 33.7±19.3 | 60.2±45.9 | 40.9±37.7 | 33.6±19.4 |
| NYHA 2 | – | 45.0±24.8 | 86.1±50.4 | 74.2±75.9 | 52.3±29.7 | |
| p Value | 0.19 | 0.08 | 0.10 | 0.04 | ||
| Severe valve disease, n (%) | NYHA 1 | – | 2 (12) | 1 (6) | 19 (58) | 13 (81) |
| NYHA 2 | – | 6 (35) | 4 (29) | 5 (71) | 8 (47) | |
| p Value | 0.22 | 0.16 | 0.69 | 0.04 | ||
| LV end-diastolic volume index (mL/m2) | NYHA 1 | 52.3±12.7 | 52.8±14.4 | 46.9±9.6 | 90.3±28.6 | 80.5±11.2 |
| NYHA 2 | – | 46.6±18.1 | 39.4±11.8 | 95.7±29.5 | 72.9±15.6 | |
| p Value | 0.28 | 0.07 | 0.57 | 0.12 | ||
| LV end-systolic volume index (mL/m2) | NYHA 1 | 19.0±7.1 | 18.7±7.6 | 17.9±6.1 | 33.3±13.7 | 28.3±6.4 |
| NYHA 2 | – | 22.8±15.4 | 14.9±5.4 | 36.7±16.8 | 25.6±6.5 | |
| p Value | 0.61 | 0.18 | 0.50 | 0.61 | ||
| LV ejection fraction (%) | NYHA 1 | 65±8 | 63±8 | 62±9 | 64±6.2 | 65±7 |
| NYHA 2 | – | 61±6 | 63±4 | 63±7 | 65±6 | |
| p Value | 0.32 | 0.86 | 0.80 | 0.96 | ||
| LA area index (cm2/m2) | NYHA 1 | 10.6±1.9 | 11.5±2.5 | 18.2±6.0 | 10.6±2.0 | 17.4±3.9 |
| NYHA 2 | – | 11.4±2.6 | 20.5±5.9 | 11.8±2.0 | 17.6±5.0 | |
| p Value | 0.90 | 0.16 | 0.14 | 0.73 | ||
| Pulmonary artery pressure (mm Hg) | NYHA 1 | 25±4 | 30±7 | 32±14 | 28±6 | 32±6 |
| NYHA 2 | – | 35±6 | 40±8 | 31±9 | 42±16 | |
| p Value | 0.06 | 0.01 | 0.19 | 0.03 | ||
| Valve area index/EROA index (cm2/m2) | NYHA 1 | – | 0.51±0.09 | 0.71±0.15 | 0.11±0.07 | 0.38±0.16 |
| NYHA 2 | – | 0.45±0.14 | 0.62±0.16 | 0.16±0.07 | 0.29±0.15 | |
| p Value | 0.15 | 0.13 | 0.06 | 0.10 | ||
| Exercise capacity (METS) | NYHA 1 | 12.6±3.1 | 10.9±2.8 | 7.0±3.0 | 11.3±3.6 | 11.1±1.6 |
| NYHA 2 | – | 7.4±2.5 | 5.5±2.0 | 9.4±1.9 | 7.2±2.1 | |
| p Value | 0.003 | 0.19 | 0.26 | <0.0001 |
BNP, brain natriuretic peptide; EROA, effective regurgitant orifice area; LA, left atrium; LV, left ventricle; NYHA, New York Heart Association.